Integration of DIGE and Bioinformatics Analyses Reveals a Role of the Antiobesity Agent Tungstate in Redox and Energy Homeostasis Pathways in Brown Adipose Tissue

Our previous results demonstrated that tungstate decreased weight gain and adiposity in obese rats through increased thermogenesis and lipid oxidation, suggesting that brown adipose tissue was one of the targets of its antiobesity effect. To identify potential targets of tungstate, we used DIGE to c...

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Veröffentlicht in:	Molecular & cellular proteomics 2008-02, Vol.7 (2), p.378-393
Hauptverfasser:	Barceló-Batllori, Sílvia, Kalko, Susana G., Esteban, Yaiza, Moreno, Sílvia, Carmona, María C., Gomis, Ramon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - chemistry Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Animals Anti-Obesity Agents - pharmacology Antioxidants - metabolism Caloric Restriction Computational Biology - methods Electrophoresis, Gel, Two-Dimensional - methods Energy Metabolism - drug effects Gene Expression Regulation - drug effects Homeostasis - drug effects Ion Channels - metabolism Lipid Metabolism - drug effects Male Mitochondrial Proteins - metabolism Oxidation-Reduction - drug effects Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Proteome - chemistry Proteome - metabolism Rats Rats, Wistar RNA-Binding Proteins Software Transcription Factors - genetics Transcription Factors - metabolism Tungsten Compounds - pharmacology Uncoupling Protein 1
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