Dexmedetomidine, an Alpha 2a Adrenergic Receptor Agonist, Mitigates Experimental Autoimmune Encephalomyelitis by Desensitization of CXCR7 in Microglia

The autoimmune disease multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), is characterized by an ascending paralysis that is characterized by extensive infiltration of the central nervous system by inflammatory cells. Although several studies to some exten...

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Veröffentlicht in:	Biochemistry (Easton) 2018-07, Vol.57 (28), p.4197-4205
Hauptverfasser:	Huang, Yi, Hu, Shite, Li, Yongliang, Xue, Dan, Wu, Xiuguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Agonists - therapeutic use Animals Cell Migration Inhibition - drug effects Cells, Cultured Dexmedetomidine - therapeutic use Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Mice, Inbred C57BL Microglia - drug effects Microglia - immunology Microglia - pathology Receptors, CXCR - analysis Receptors, CXCR - immunology
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