D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations. D-2HG acting as an oncometabolite promotes proliferation, anoikis, and differentiation block of hematopoietic...

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Veröffentlicht in:	Oncoimmunology 2018-07, Vol.7 (7), p.e1445454-e1445454
Hauptverfasser:	Böttcher, Martin, Renner, Kathrin, Berger, Raffaela, Mentz, Kristin, Thomas, Simone, Cardenas-Conejo, Zugey Elizabeth, Dettmer, Katja, Oefner, Peter J., Mackensen, Andreas, Kreutz, Marina, Mougiakakos, Dimitrios
Format:	Artikel
Sprache:	eng
Schlagworte:	2HG acute myeloid leukemia IDH mutation immunometabolism Immunosurveillance Inflammation and cancer oncometabolite Original Research Th17 Tregs
Online-Zugang:	Volltext
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