Anti-mouse CD52 Treatment Ameliorates Colitis through Suppressing Th1/17 Mediated Inflammation and Promoting Tregs Differentiation in IL-10 Deficient Mice

Recent studies suggested that excessive T helper (Th)1/17 cells concomitant with regulatory T cell deficiency might play important roles in Crohn’s disease. Anti-cluster of differentiation 52 (CD52) monoclonal antibody (mAb), which aims on CD52 antigen on mature immunocytes, has both T cell depletio...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2018/09/01, Vol.41(9), pp.1423-1429
Hauptverfasser:	Liu, Jianhui, Wang, Honggang, Li, Yi, Shi, Peiliang, Gong, Jianfeng, Gu, Lili, Zhu, Weiming, Li, Jieshou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-cluster of differentiation 52 (CD52) monoclonal antibody Body weight CD25 antigen CD52 antigen CD52 Antigen - antagonists & inhibitors CD52 Antigen - metabolism Cell differentiation Cell Differentiation - drug effects Cell Differentiation - physiology Colitis Colitis - drug therapy Colitis - metabolism Colon Crohn’s disease Depletion Female Forkhead protein Foxp3 protein Gene expression Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Inflammatory bowel disease Interferon Interleukin 10 Interleukin 17 Interleukin 6 interleukin-10 (IL-10) deficient mouse Interleukin-10 - deficiency Lamina propria Leukocytes (mononuclear) Lymphocytes Lymphocytes T Male Medical treatment Mice Mice, Inbred C3H Mice, Knockout Monoclonal antibodies T cell T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Th1 Cells - drug effects Th1 Cells - metabolism Th17 Cells - drug effects Th17 Cells - metabolism Therapeutic applications Transforming growth factor Treatment Outcome Tumor necrosis factor-TNF Tumor necrosis factor-α γ-Interferon
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