Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy
Each of two dogs presented for multiple skin biopsies were sedated with intravenous medetomidine and lignocaine was injected subcutaneously to provide local anaesthesia for skin biopsy. One dog had a seizure during skin biopsy and again immediately following reversal of medetomidine with atipamezole...
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| Veröffentlicht in: | Australian veterinary journal 2009-05, Vol.87 (5), p.188-192 |
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| container_title | Australian veterinary journal |
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| creator | Rainger, J.E Baxter, C.G Vogelnest, L.J Dart, C.M |
| description | Each of two dogs presented for multiple skin biopsies were sedated with intravenous medetomidine and lignocaine was injected subcutaneously to provide local anaesthesia for skin biopsy. One dog had a seizure during skin biopsy and again immediately following reversal of medetomidine with atipamezole. The other dog developed seizures 2 h following skin biopsy at which time the medetomidine was reversed with atipamezole. Both dogs were neurologically normal with no history of seizures prior to the procedure and remained neurologically normal for 14 weeks and 9 months, respectively, following the procedure. A drug interaction between the α2‐adrenergic agonist medetomidine and lignocaine is suspected and highlights the potential for seizures following the subcutaneous administration of relatively large doses of lignocaine under medetomidine sedation. |
| doi_str_mv | 10.1111/j.1751-0813.2009.00419.x |
| format | Article |
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One dog had a seizure during skin biopsy and again immediately following reversal of medetomidine with atipamezole. The other dog developed seizures 2 h following skin biopsy at which time the medetomidine was reversed with atipamezole. Both dogs were neurologically normal with no history of seizures prior to the procedure and remained neurologically normal for 14 weeks and 9 months, respectively, following the procedure. A drug interaction between the α2‐adrenergic agonist medetomidine and lignocaine is suspected and highlights the potential for seizures following the subcutaneous administration of relatively large doses of lignocaine under medetomidine sedation.</description><identifier>ISSN: 0005-0423</identifier><identifier>EISSN: 1751-0813</identifier><identifier>DOI: 10.1111/j.1751-0813.2009.00419.x</identifier><identifier>PMID: 19382926</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>adverse effects ; anesthesia ; anesthetics ; Anesthetics, Local - adverse effects ; Animals ; atipamezole ; biopsy ; Biopsy - veterinary ; case studies ; Dermatitis, Atopic - pathology ; Dermatitis, Atopic - veterinary ; dog diseases ; Dog Diseases - chemically induced ; Dog Diseases - pathology ; DOGS ; Drug Interactions ; Fatal Outcome ; Female ; Hypnotics and Sedatives - adverse effects ; Immunosuppressive Agents - therapeutic use ; intravenous injection ; Lidocaine - adverse effects ; lignocaine ; medetomidine ; Medetomidine - adverse effects ; Pemphigus - drug therapy ; Pemphigus - pathology ; Pemphigus - veterinary ; postoperative complications ; sedation ; seizures ; Seizures - chemically induced ; Seizures - veterinary ; subcutaneous injection ; Treatment Outcome</subject><ispartof>Australian veterinary journal, 2009-05, Vol.87 (5), p.188-192</ispartof><rights>2009 University of Sydney. 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One dog had a seizure during skin biopsy and again immediately following reversal of medetomidine with atipamezole. The other dog developed seizures 2 h following skin biopsy at which time the medetomidine was reversed with atipamezole. Both dogs were neurologically normal with no history of seizures prior to the procedure and remained neurologically normal for 14 weeks and 9 months, respectively, following the procedure. A drug interaction between the α2‐adrenergic agonist medetomidine and lignocaine is suspected and highlights the potential for seizures following the subcutaneous administration of relatively large doses of lignocaine under medetomidine sedation.</description><subject>adverse effects</subject><subject>anesthesia</subject><subject>anesthetics</subject><subject>Anesthetics, Local - adverse effects</subject><subject>Animals</subject><subject>atipamezole</subject><subject>biopsy</subject><subject>Biopsy - veterinary</subject><subject>case studies</subject><subject>Dermatitis, Atopic - pathology</subject><subject>Dermatitis, Atopic - veterinary</subject><subject>dog diseases</subject><subject>Dog Diseases - chemically induced</subject><subject>Dog Diseases - pathology</subject><subject>DOGS</subject><subject>Drug Interactions</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Hypnotics and Sedatives - adverse effects</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>intravenous injection</subject><subject>Lidocaine - adverse effects</subject><subject>lignocaine</subject><subject>medetomidine</subject><subject>Medetomidine - adverse effects</subject><subject>Pemphigus - drug therapy</subject><subject>Pemphigus - pathology</subject><subject>Pemphigus - veterinary</subject><subject>postoperative complications</subject><subject>sedation</subject><subject>seizures</subject><subject>Seizures - chemically induced</subject><subject>Seizures - veterinary</subject><subject>subcutaneous injection</subject><subject>Treatment Outcome</subject><issn>0005-0423</issn><issn>1751-0813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtP4zAUhS00CDrAXwCvZpfMtR3nIbFBCBgQEotStpbjR8edNC52o1J-PQ6tmC3e-Mr3nON7P4QwgZyk83uRk4qTDGrCcgrQ5AAFafK3AzT5avxAEwDgGRSUHaOfMS4AWMUpP0LHpGE1bWg5QWJq3PsQTMR6CK6f46XRZu2XrteuNzgaLdfO91j2GndeyS5V0sT1XxOdxK7H643H2s8jHnptwtyPGfFfarTOr-L2FB1a2UVztr9P0Oz25vn6T_b4dHd_ffWYqaIiTdYaXmnSMl6WtbIKtG0qVSmlOCvAVqzSrbWFpC2XvLCM142q00spVd2AAsJO0K9d7ir41yENKJYuKtN1sjd-iIIC55SUkIT1TqiCjzEYK1bBLWXYCgJihCsWYmQoRoZihCs-4Yq3ZD3f_zG0CdN_455mElzuBBvXme23g8XVy0Mqkv1iZ7fSCzkPLorZlKblgJSME8rZBwd2kzU</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Rainger, J.E</creator><creator>Baxter, C.G</creator><creator>Vogelnest, L.J</creator><creator>Dart, C.M</creator><general>Blackwell Publishing Asia</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200905</creationdate><title>Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy</title><author>Rainger, J.E ; Baxter, C.G ; Vogelnest, L.J ; Dart, C.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4719-be57d1b35668cfc0df97c7ccc5340f737dbff4a2b5a54f3589c8bff6ac890c013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>adverse effects</topic><topic>anesthesia</topic><topic>anesthetics</topic><topic>Anesthetics, Local - adverse effects</topic><topic>Animals</topic><topic>atipamezole</topic><topic>biopsy</topic><topic>Biopsy - veterinary</topic><topic>case studies</topic><topic>Dermatitis, Atopic - pathology</topic><topic>Dermatitis, Atopic - veterinary</topic><topic>dog diseases</topic><topic>Dog Diseases - chemically induced</topic><topic>Dog Diseases - pathology</topic><topic>DOGS</topic><topic>Drug Interactions</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Hypnotics and Sedatives - adverse effects</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>intravenous injection</topic><topic>Lidocaine - adverse effects</topic><topic>lignocaine</topic><topic>medetomidine</topic><topic>Medetomidine - adverse effects</topic><topic>Pemphigus - drug therapy</topic><topic>Pemphigus - pathology</topic><topic>Pemphigus - veterinary</topic><topic>postoperative complications</topic><topic>sedation</topic><topic>seizures</topic><topic>Seizures - chemically induced</topic><topic>Seizures - veterinary</topic><topic>subcutaneous injection</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rainger, J.E</creatorcontrib><creatorcontrib>Baxter, C.G</creatorcontrib><creatorcontrib>Vogelnest, L.J</creatorcontrib><creatorcontrib>Dart, C.M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Australian veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rainger, J.E</au><au>Baxter, C.G</au><au>Vogelnest, L.J</au><au>Dart, C.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy</atitle><jtitle>Australian veterinary journal</jtitle><addtitle>Aust Vet J</addtitle><date>2009-05</date><risdate>2009</risdate><volume>87</volume><issue>5</issue><spage>188</spage><epage>192</epage><pages>188-192</pages><issn>0005-0423</issn><eissn>1751-0813</eissn><abstract>Each of two dogs presented for multiple skin biopsies were sedated with intravenous medetomidine and lignocaine was injected subcutaneously to provide local anaesthesia for skin biopsy. One dog had a seizure during skin biopsy and again immediately following reversal of medetomidine with atipamezole. The other dog developed seizures 2 h following skin biopsy at which time the medetomidine was reversed with atipamezole. Both dogs were neurologically normal with no history of seizures prior to the procedure and remained neurologically normal for 14 weeks and 9 months, respectively, following the procedure. A drug interaction between the α2‐adrenergic agonist medetomidine and lignocaine is suspected and highlights the potential for seizures following the subcutaneous administration of relatively large doses of lignocaine under medetomidine sedation.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19382926</pmid><doi>10.1111/j.1751-0813.2009.00419.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | adverse effects anesthesia anesthetics Anesthetics, Local - adverse effects Animals atipamezole biopsy Biopsy - veterinary case studies Dermatitis, Atopic - pathology Dermatitis, Atopic - veterinary dog diseases Dog Diseases - chemically induced Dog Diseases - pathology DOGS Drug Interactions Fatal Outcome Female Hypnotics and Sedatives - adverse effects Immunosuppressive Agents - therapeutic use intravenous injection Lidocaine - adverse effects lignocaine medetomidine Medetomidine - adverse effects Pemphigus - drug therapy Pemphigus - pathology Pemphigus - veterinary postoperative complications sedation seizures Seizures - chemically induced Seizures - veterinary subcutaneous injection Treatment Outcome |
| title | Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy |
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