Increased rewarding properties of morphine in perinatally protein-malnourished rats

Abstract In the current research, we assessed the influence of a protein malnutrition schedule from the 14th day of gestation up to 40 days of age (D-rats) on the rewarding properties of morphine in adult rats by means of the conditioned place preference paradigm. Well-nourished animals (C-rats) adm...

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Veröffentlicht in:	Neuroscience 2007-12, Vol.150 (2), p.449-458
Hauptverfasser:	Valdomero, A, Velazquez, E.E, de Olmos, S, De Olmos, J.S, Orsingher, O.A, Cuadra, G.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - drug effects Amygdala - metabolism Amygdala - physiopathology Analgesics Animals Biological and medical sciences Brain - drug effects Brain - metabolism Brain - physiopathology conditioned place preference Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Female Fetal Nutrition Disorders - physiopathology FosB expression Fundamental and applied biological sciences. Psychology Limbic System - drug effects Limbic System - metabolism Limbic System - physiopathology Medical sciences morphine Morphine - pharmacology Morphine Dependence - metabolism Morphine Dependence - physiopathology Narcotics - pharmacology Neurology Neuropharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Nucleus Accumbens - physiopathology perinatal undernutrition Pharmacology. Drug treatments Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Pregnancy Protein Deficiency - physiopathology Proto-Oncogene Proteins c-fos - drug effects Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Wistar Reward sensitization Up-Regulation - drug effects Up-Regulation - physiology Vertebrates: nervous system and sense organs
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