Chronopharmacology of Morphine in Mice

Dosing-time-dependent changes in the effect and toxicity of morphine were examined in mice housed under alternating 12 h light (07:00 to 19:00 h) and dark (19:00 to 07:00 h) cycles. Morphine (0.5 mg kg) was injected intraperitoneally (i.p.) in animals to assess its beneficial effect (i.e., protectio...

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Veröffentlicht in:	Chronobiology international 2005-01, Vol.22 (3), p.515-522
Hauptverfasser:	Cui, Yimin, Sugimoto, Koh-ichi, Araki, Nobutaka, Sudoh, Toshiaki, Fujimura, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Analgesia Animals Antidiarrheals - administration & dosage Aspartate Aminotransferases - blood Chronopharmacology Chronotoxicity Circadian Rhythm Circadian Rhythm - physiology Glutathione Glutathione - metabolism Hepatotoxicity Kaolin - administration & dosage Liver - drug effects Liver - enzymology Male Mice Morphine Morphine - metabolism Morphine - therapeutic use Morphine - toxicity Narcotics - metabolism Narcotics - therapeutic use Narcotics - toxicity Pain - chemically induced Pain - drug therapy Photoperiod Time Factors
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