$Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia$

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

The oral BCL-2 inhibitor venetoclax is an effective therapy for patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), including disease with high-risk genomic features such as chromosome 17p deletion [del(17p)] or progressive disease following B-cell receptor pathway inhibitors...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2018-09, Vol.24 (18), p.4371-4379
Hauptverfasser:	Davids, Matthew S, Hallek, Michael, Wierda, William, Roberts, Andrew W, Stilgenbauer, Stephan, Jones, Jeffrey A, Gerecitano, John F, Kim, Su Young, Potluri, Jalaja, Busman, Todd, Best, Andrea, Verdugo, Maria E, Cerri, Elisa, Desai, Monali, Hillmen, Peter, Seymour, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - adverse effects Bridged Bicyclo Compounds, Heterocyclic - therapeutic use Chromosome Deletion Chromosomes, Human, Pair 17 - genetics Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Drug-Related Side Effects and Adverse Reactions - classification Drug-Related Side Effects and Adverse Reactions - pathology Female Gastrointestinal Tract - drug effects Gastrointestinal Tract - pathology Gene Expression Regulation, Neoplastic - drug effects Humans Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male Middle Aged Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - genetics Smith-Magenis Syndrome - drug therapy Smith-Magenis Syndrome - genetics Smith-Magenis Syndrome - pathology Sulfonamides - administration & dosage Sulfonamides - adverse effects Sulfonamides - therapeutic use Treatment Outcome Tumor Suppressor Protein p53 - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!