Genetic Variation in the H19-IGF2 Cluster Might Confer Risk of Developing Impaired Renal Function

The H19-IGF2 imprinted gene region could be implicated in the risk of developing impaired renal function (IRF). Our aim was to determine the association of several common H19-IGF2 variants and IRF in a cohort of elderly healthy individuals. The study involved 675 individuals >65 years of age, 184...

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Veröffentlicht in:	DNA and cell biology 2018-07, Vol.37 (7), p.617-625
Hauptverfasser:	Coto, Eliecer, Díaz Corte, Carmen, Tranche, Salvador, Gómez, Juan, Reguero, Julián R, Alonso, Belén, Iglesias, Sara, Gil-Peña, Helena, Yin, Xueqian, Coto-Segura, Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Confidence intervals Deoxyribonucleic acid Diabetes mellitus Diabetes mellitus (non-insulin dependent) DNA DNA methylation Endonuclease Epidermal growth factor receptors Genetic diversity Genotyping Geriatrics Glomerular filtration rate Insulin-like growth factor II Older people Renal function Risk Single-nucleotide polymorphism
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Zusammenfassung:	The H19-IGF2 imprinted gene region could be implicated in the risk of developing impaired renal function (IRF). Our aim was to determine the association of several common H19-IGF2 variants and IRF in a cohort of elderly healthy individuals. The study involved 675 individuals >65 years of age, 184 with type 2 diabetes mellitus (T2DM), and 105 with IRF (estimated glomerular filtration rate [eGFR]
ISSN:	1044-5498 1557-7430
DOI:	10.1089/dna.2017.4135