Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease
Summary Background Youths with inflammatory bowel disease (IBD) are at risk for developing anxiety and depressive symptoms with a reported 20%‐50% prevalence rate. Aims This prospective study aimed to: (1) describe the prevalence and severity of anxiety and depressive symptoms in a large Dutch cohor...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2018-08, Vol.48 (3), p.358-369 |
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| creator | van den Brink, G. Stapersma, L. Vlug, L. E. Rizopolous, D. Bodelier, A. G. Wering, H. Hurkmans, P. C. W. M. Stuyt, R. J. L. Hendriks, D. M. Burg, J. A. T. Utens, E. M. W. J. Escher, J. C. |
| description | Summary
Background
Youths with inflammatory bowel disease (IBD) are at risk for developing anxiety and depressive symptoms with a reported 20%‐50% prevalence rate.
Aims
This prospective study aimed to: (1) describe the prevalence and severity of anxiety and depressive symptoms in a large Dutch cohort of young IBD patients, and (2) identify demographic and clinical risk factors for anxiety and depression.
Methods
IBD patients (n = 374; 10‐25 years) were screened for anxiety, depression and quality of life using validated age‐specific questionnaires. Patients with elevated scores for anxiety and/or depressive symptoms received a diagnostic interview assessing psychiatric disorders. Demographic and clinical characteristics were retrieved from medical charts. Multiple logistic regression analysis was performed to identify risk factors for anxiety and/or depression.
Results
Patients (mean age 18.9 years, 44.1% male, Crohn's disease 60.4%) had disease in remission (75.4%), or mild, moderate and severe clinical disease activity in, respectively, 19.8%, 2.7% and 2.1%. Mild anxiety/depressive symptoms were present in 35.2% and severe symptoms in 12.4% of patients. Elevated symptoms of either anxiety (28.3%), depression (2.9%) or both (15.8%) were found and did not differ between adolescents (10‐17 years) and young adults (18‐25 years). Active disease significantly predicted depressive symptoms (odds ratio (OR): 4.6 [95% confidence interval [CI]: 2.4‐8.8], P < 0.001). Female gender (OR: 1.7 [95% CI: 1.1‐2.7]), active disease (OR: 1.9 [95% CI: 1.1‐3.2]) and a shorter disease duration (OR: 1.3 [95% CI: 0.6‐1.0) (all P < 0.025) significantly predicted anxiety and/or depressive symptoms.
Conclusions
Considering the high prevalence of anxiety and depressive symptoms, psychological screening is recommended in young IBD patients. Screening facilitates early recognition and psychological treatment. Female patients and patients with active disease are the most vulnerable. |
| doi_str_mv | 10.1111/apt.14832 |
| format | Article |
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Background
Youths with inflammatory bowel disease (IBD) are at risk for developing anxiety and depressive symptoms with a reported 20%‐50% prevalence rate.
Aims
This prospective study aimed to: (1) describe the prevalence and severity of anxiety and depressive symptoms in a large Dutch cohort of young IBD patients, and (2) identify demographic and clinical risk factors for anxiety and depression.
Methods
IBD patients (n = 374; 10‐25 years) were screened for anxiety, depression and quality of life using validated age‐specific questionnaires. Patients with elevated scores for anxiety and/or depressive symptoms received a diagnostic interview assessing psychiatric disorders. Demographic and clinical characteristics were retrieved from medical charts. Multiple logistic regression analysis was performed to identify risk factors for anxiety and/or depression.
Results
Patients (mean age 18.9 years, 44.1% male, Crohn's disease 60.4%) had disease in remission (75.4%), or mild, moderate and severe clinical disease activity in, respectively, 19.8%, 2.7% and 2.1%. Mild anxiety/depressive symptoms were present in 35.2% and severe symptoms in 12.4% of patients. Elevated symptoms of either anxiety (28.3%), depression (2.9%) or both (15.8%) were found and did not differ between adolescents (10‐17 years) and young adults (18‐25 years). Active disease significantly predicted depressive symptoms (odds ratio (OR): 4.6 [95% confidence interval [CI]: 2.4‐8.8], P < 0.001). Female gender (OR: 1.7 [95% CI: 1.1‐2.7]), active disease (OR: 1.9 [95% CI: 1.1‐3.2]) and a shorter disease duration (OR: 1.3 [95% CI: 0.6‐1.0) (all P < 0.025) significantly predicted anxiety and/or depressive symptoms.
Conclusions
Considering the high prevalence of anxiety and depressive symptoms, psychological screening is recommended in young IBD patients. Screening facilitates early recognition and psychological treatment. Female patients and patients with active disease are the most vulnerable.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.14832</identifier><identifier>PMID: 29897134</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescents ; Anxiety ; Crohn's disease ; Demographics ; Health risk assessment ; Health risks ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Intestine ; Medical treatment ; Mental depression ; Mental disorders ; Patients ; Quality of life ; Regression analysis ; Remission ; Risk factors ; Young adults</subject><ispartof>Alimentary pharmacology & therapeutics, 2018-08, Vol.48 (3), p.358-369</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-34b34af686b848f313f53643ecb0b9e4f3b8e57e4d8e34928d51af9069b639fb3</citedby><cites>FETCH-LOGICAL-c3882-34b34af686b848f313f53643ecb0b9e4f3b8e57e4d8e34928d51af9069b639fb3</cites><orcidid>0000-0001-6430-8184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.14832$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.14832$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29897134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van den Brink, G.</creatorcontrib><creatorcontrib>Stapersma, L.</creatorcontrib><creatorcontrib>Vlug, L. E.</creatorcontrib><creatorcontrib>Rizopolous, D.</creatorcontrib><creatorcontrib>Bodelier, A. G.</creatorcontrib><creatorcontrib>Wering, H.</creatorcontrib><creatorcontrib>Hurkmans, P. C. W. M.</creatorcontrib><creatorcontrib>Stuyt, R. J. L.</creatorcontrib><creatorcontrib>Hendriks, D. M.</creatorcontrib><creatorcontrib>Burg, J. A. T.</creatorcontrib><creatorcontrib>Utens, E. M. W. J.</creatorcontrib><creatorcontrib>Escher, J. C.</creatorcontrib><title>Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Youths with inflammatory bowel disease (IBD) are at risk for developing anxiety and depressive symptoms with a reported 20%‐50% prevalence rate.
Aims
This prospective study aimed to: (1) describe the prevalence and severity of anxiety and depressive symptoms in a large Dutch cohort of young IBD patients, and (2) identify demographic and clinical risk factors for anxiety and depression.
Methods
IBD patients (n = 374; 10‐25 years) were screened for anxiety, depression and quality of life using validated age‐specific questionnaires. Patients with elevated scores for anxiety and/or depressive symptoms received a diagnostic interview assessing psychiatric disorders. Demographic and clinical characteristics were retrieved from medical charts. Multiple logistic regression analysis was performed to identify risk factors for anxiety and/or depression.
Results
Patients (mean age 18.9 years, 44.1% male, Crohn's disease 60.4%) had disease in remission (75.4%), or mild, moderate and severe clinical disease activity in, respectively, 19.8%, 2.7% and 2.1%. Mild anxiety/depressive symptoms were present in 35.2% and severe symptoms in 12.4% of patients. Elevated symptoms of either anxiety (28.3%), depression (2.9%) or both (15.8%) were found and did not differ between adolescents (10‐17 years) and young adults (18‐25 years). Active disease significantly predicted depressive symptoms (odds ratio (OR): 4.6 [95% confidence interval [CI]: 2.4‐8.8], P < 0.001). Female gender (OR: 1.7 [95% CI: 1.1‐2.7]), active disease (OR: 1.9 [95% CI: 1.1‐3.2]) and a shorter disease duration (OR: 1.3 [95% CI: 0.6‐1.0) (all P < 0.025) significantly predicted anxiety and/or depressive symptoms.
Conclusions
Considering the high prevalence of anxiety and depressive symptoms, psychological screening is recommended in young IBD patients. Screening facilitates early recognition and psychological treatment. Female patients and patients with active disease are the most vulnerable.</description><subject>Adolescents</subject><subject>Anxiety</subject><subject>Crohn's disease</subject><subject>Demographics</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Intestine</subject><subject>Medical treatment</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Patients</subject><subject>Quality of life</subject><subject>Regression analysis</subject><subject>Remission</subject><subject>Risk factors</subject><subject>Young adults</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi1ERZfCgT-ALHGBQ1p_xWsfqxVfUqX2UM6RnYzBlWOH2OmS_8CPxt0tPSAxl5FmHj0z0ovQG0rOaa0LM5VzKhRnz9CGctk2jHD5HG0Ik7phivJT9DLnO0KI3BL2Ap0yrfSWcrFBv3fBR9-bgAefwWTApi_-3pcV-4xNzqn3psCA9778wCb-8lBXJg54gGmGnP094LyOU0ljxj5iM6QAuYdY8gFb0xK_1-kS6uAg8dEFM46mpHnFNu3h6fYrdOJMyPD6sZ-hb58-3u6-NFfXn7_uLq-anivFGi4sF8ZJJa0SynHKXcul4NBbYjUIx62CdgtiUMCFZmpoqXGaSG0l187yM_T-6J3m9HOBXLrR15dDMBHSkjtGWqGrVpCKvvsHvUvLHOt3lZKKUdqytlIfjlQ_p5xncN00-9HMa0dJ9xBRVyPqDhFV9u2jcbEjDE_k30wqcHEE9j7A-n9Td3lze1T-AV_7nU0</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>van den Brink, G.</creator><creator>Stapersma, L.</creator><creator>Vlug, L. E.</creator><creator>Rizopolous, D.</creator><creator>Bodelier, A. G.</creator><creator>Wering, H.</creator><creator>Hurkmans, P. C. W. M.</creator><creator>Stuyt, R. J. L.</creator><creator>Hendriks, D. M.</creator><creator>Burg, J. A. T.</creator><creator>Utens, E. M. W. J.</creator><creator>Escher, J. C.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6430-8184</orcidid></search><sort><creationdate>201808</creationdate><title>Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease</title><author>van den Brink, G. ; Stapersma, L. ; Vlug, L. E. ; Rizopolous, D. ; Bodelier, A. G. ; Wering, H. ; Hurkmans, P. C. W. M. ; Stuyt, R. J. L. ; Hendriks, D. M. ; Burg, J. A. T. ; Utens, E. M. W. J. ; Escher, J. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-34b34af686b848f313f53643ecb0b9e4f3b8e57e4d8e34928d51af9069b639fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescents</topic><topic>Anxiety</topic><topic>Crohn's disease</topic><topic>Demographics</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Intestine</topic><topic>Medical treatment</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Patients</topic><topic>Quality of life</topic><topic>Regression analysis</topic><topic>Remission</topic><topic>Risk factors</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van den Brink, G.</creatorcontrib><creatorcontrib>Stapersma, L.</creatorcontrib><creatorcontrib>Vlug, L. E.</creatorcontrib><creatorcontrib>Rizopolous, D.</creatorcontrib><creatorcontrib>Bodelier, A. G.</creatorcontrib><creatorcontrib>Wering, H.</creatorcontrib><creatorcontrib>Hurkmans, P. C. W. M.</creatorcontrib><creatorcontrib>Stuyt, R. J. L.</creatorcontrib><creatorcontrib>Hendriks, D. M.</creatorcontrib><creatorcontrib>Burg, J. A. T.</creatorcontrib><creatorcontrib>Utens, E. M. W. J.</creatorcontrib><creatorcontrib>Escher, J. C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van den Brink, G.</au><au>Stapersma, L.</au><au>Vlug, L. E.</au><au>Rizopolous, D.</au><au>Bodelier, A. G.</au><au>Wering, H.</au><au>Hurkmans, P. C. W. M.</au><au>Stuyt, R. J. L.</au><au>Hendriks, D. M.</au><au>Burg, J. A. T.</au><au>Utens, E. M. W. J.</au><au>Escher, J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2018-08</date><risdate>2018</risdate><volume>48</volume><issue>3</issue><spage>358</spage><epage>369</epage><pages>358-369</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Youths with inflammatory bowel disease (IBD) are at risk for developing anxiety and depressive symptoms with a reported 20%‐50% prevalence rate.
Aims
This prospective study aimed to: (1) describe the prevalence and severity of anxiety and depressive symptoms in a large Dutch cohort of young IBD patients, and (2) identify demographic and clinical risk factors for anxiety and depression.
Methods
IBD patients (n = 374; 10‐25 years) were screened for anxiety, depression and quality of life using validated age‐specific questionnaires. Patients with elevated scores for anxiety and/or depressive symptoms received a diagnostic interview assessing psychiatric disorders. Demographic and clinical characteristics were retrieved from medical charts. Multiple logistic regression analysis was performed to identify risk factors for anxiety and/or depression.
Results
Patients (mean age 18.9 years, 44.1% male, Crohn's disease 60.4%) had disease in remission (75.4%), or mild, moderate and severe clinical disease activity in, respectively, 19.8%, 2.7% and 2.1%. Mild anxiety/depressive symptoms were present in 35.2% and severe symptoms in 12.4% of patients. Elevated symptoms of either anxiety (28.3%), depression (2.9%) or both (15.8%) were found and did not differ between adolescents (10‐17 years) and young adults (18‐25 years). Active disease significantly predicted depressive symptoms (odds ratio (OR): 4.6 [95% confidence interval [CI]: 2.4‐8.8], P < 0.001). Female gender (OR: 1.7 [95% CI: 1.1‐2.7]), active disease (OR: 1.9 [95% CI: 1.1‐3.2]) and a shorter disease duration (OR: 1.3 [95% CI: 0.6‐1.0) (all P < 0.025) significantly predicted anxiety and/or depressive symptoms.
Conclusions
Considering the high prevalence of anxiety and depressive symptoms, psychological screening is recommended in young IBD patients. Screening facilitates early recognition and psychological treatment. Female patients and patients with active disease are the most vulnerable.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29897134</pmid><doi>10.1111/apt.14832</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6430-8184</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals |
| subjects | Adolescents Anxiety Crohn's disease Demographics Health risk assessment Health risks Inflammatory bowel disease Inflammatory bowel diseases Intestine Medical treatment Mental depression Mental disorders Patients Quality of life Regression analysis Remission Risk factors Young adults |
| title | Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease |
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