Granulocyte colony-stimulating factor utilization postautologous hematopoietic stem cell transplant in multiple myeloma patients: Does one size fit all?
Purpose To evaluate a single institution’s experience with granulocyte colony-stimulating factor after autologous hematopoietic stem cell transplant in myeloma patients to identify populations that benefit most from granulocyte colony-stimulating factor administration. Methods Retrospective chart re...
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| Veröffentlicht in: | Journal of oncology pharmacy practice 2019-07, Vol.25 (5), p.1135-1141 |
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| creator | Jackson, Emily R Jared, Jason R Piccolo, Jennifer K Woo, Kaitlin M Mably, Mary S Reed, Michael P Callander, Natalie S |
| description | Purpose
To evaluate a single institution’s experience with granulocyte colony-stimulating factor after autologous hematopoietic stem cell transplant in myeloma patients to identify populations that benefit most from granulocyte colony-stimulating factor administration.
Methods
Retrospective chart reviews were conducted on patients 18+ years with multiple myeloma that underwent autologous hematopoietic stem cell transplant at UW Health from January 2012 to May 2016. Data collection included demographics, length of stay, time to engraftment, Eastern Cooperative Oncology Group performance status score, and hematopoietic cell transplantation-comorbidity index. The primary outcome was days from transplant to engraftment, defined as absolute neutrophil count > 500/mm3 for two consecutive days or absolute neutrophil count > 1000/mm3 once. A subset analysis was performed on patients whose date of engraftment was known.
Results
In total, 216 individual patients were included in the full cohort and 122 patients included in the subset analysis. Median time to engraftment between patients administered granulocyte colony-stimulating factor and the nongranulocyte colony-stimulating factor group was 12 versus 19 days (P |
| doi_str_mv | 10.1177/1078155218781888 |
| format | Article |
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To evaluate a single institution’s experience with granulocyte colony-stimulating factor after autologous hematopoietic stem cell transplant in myeloma patients to identify populations that benefit most from granulocyte colony-stimulating factor administration.
Methods
Retrospective chart reviews were conducted on patients 18+ years with multiple myeloma that underwent autologous hematopoietic stem cell transplant at UW Health from January 2012 to May 2016. Data collection included demographics, length of stay, time to engraftment, Eastern Cooperative Oncology Group performance status score, and hematopoietic cell transplantation-comorbidity index. The primary outcome was days from transplant to engraftment, defined as absolute neutrophil count > 500/mm3 for two consecutive days or absolute neutrophil count > 1000/mm3 once. A subset analysis was performed on patients whose date of engraftment was known.
Results
In total, 216 individual patients were included in the full cohort and 122 patients included in the subset analysis. Median time to engraftment between patients administered granulocyte colony-stimulating factor and the nongranulocyte colony-stimulating factor group was 12 versus 19 days (P < 0.001) in the full cohort and 12 versus 14 days (P < 0.001) in the subset analysis. The average length of stay posthematopoietic stem cell transplant in the granulocyte colony-stimulating factor group was 15 days versus 17 days in the nongranulocyte colony-stimulating factor group (P = 0.026) in the subset analysis. Additionally, no difference in time to engraftment was seen when stratified by age, Eastern Cooperative Oncology Group performance status score, or hematopoietic cell transplantation-comorbidity index.
Conclusion
Our study supports use of granulocyte colony-stimulating factor posthematopoietic stem cell transplant in myeloma patients to decrease time to engraftment and length of stay. Consideration should be given to utilization in all patients in this population posthematopoietic stem cell transplant. Further research is needed to identify the populations that benefit most from granulocyte colony-stimulating factor administration.</description><identifier>ISSN: 1078-1552</identifier><identifier>EISSN: 1477-092X</identifier><identifier>DOI: 10.1177/1078155218781888</identifier><identifier>PMID: 29890920</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>Journal of oncology pharmacy practice, 2019-07, Vol.25 (5), p.1135-1141</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-90f6c6fc3f4e2373dbdfa2e50b36a3ef43e5644ec32ff8a0698c5d480f33cc813</citedby><cites>FETCH-LOGICAL-c337t-90f6c6fc3f4e2373dbdfa2e50b36a3ef43e5644ec32ff8a0698c5d480f33cc813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1078155218781888$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1078155218781888$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29890920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, Emily R</creatorcontrib><creatorcontrib>Jared, Jason R</creatorcontrib><creatorcontrib>Piccolo, Jennifer K</creatorcontrib><creatorcontrib>Woo, Kaitlin M</creatorcontrib><creatorcontrib>Mably, Mary S</creatorcontrib><creatorcontrib>Reed, Michael P</creatorcontrib><creatorcontrib>Callander, Natalie S</creatorcontrib><title>Granulocyte colony-stimulating factor utilization postautologous hematopoietic stem cell transplant in multiple myeloma patients: Does one size fit all?</title><title>Journal of oncology pharmacy practice</title><addtitle>J Oncol Pharm Pract</addtitle><description>Purpose
To evaluate a single institution’s experience with granulocyte colony-stimulating factor after autologous hematopoietic stem cell transplant in myeloma patients to identify populations that benefit most from granulocyte colony-stimulating factor administration.
Methods
Retrospective chart reviews were conducted on patients 18+ years with multiple myeloma that underwent autologous hematopoietic stem cell transplant at UW Health from January 2012 to May 2016. Data collection included demographics, length of stay, time to engraftment, Eastern Cooperative Oncology Group performance status score, and hematopoietic cell transplantation-comorbidity index. The primary outcome was days from transplant to engraftment, defined as absolute neutrophil count > 500/mm3 for two consecutive days or absolute neutrophil count > 1000/mm3 once. A subset analysis was performed on patients whose date of engraftment was known.
Results
In total, 216 individual patients were included in the full cohort and 122 patients included in the subset analysis. Median time to engraftment between patients administered granulocyte colony-stimulating factor and the nongranulocyte colony-stimulating factor group was 12 versus 19 days (P < 0.001) in the full cohort and 12 versus 14 days (P < 0.001) in the subset analysis. The average length of stay posthematopoietic stem cell transplant in the granulocyte colony-stimulating factor group was 15 days versus 17 days in the nongranulocyte colony-stimulating factor group (P = 0.026) in the subset analysis. Additionally, no difference in time to engraftment was seen when stratified by age, Eastern Cooperative Oncology Group performance status score, or hematopoietic cell transplantation-comorbidity index.
Conclusion
Our study supports use of granulocyte colony-stimulating factor posthematopoietic stem cell transplant in myeloma patients to decrease time to engraftment and length of stay. Consideration should be given to utilization in all patients in this population posthematopoietic stem cell transplant. Further research is needed to identify the populations that benefit most from granulocyte colony-stimulating factor administration.</description><issn>1078-1552</issn><issn>1477-092X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kbtrHDEQh0VI8CvuU4Up06ytxz60bkJw_AgY0sSQbtHpRhcZrbRezRbnvyR_rnWcnSLgaoTmmw9-M4x9EvxMiK47F7zTommk0KVqrd-xI1F3XcV7-ft9eZd2tesfsuOcHzjnupP6gB3KXveF4Ufs781s4hKS3RKCTSHFbZXJj0sw5OMGnLGUZljIB_9UvlKEKWUyCxV2k5YMf3A0lKbkkbyFTDiCxRCAijhPwUQCH6EIyU8BYdxiSKOBqcgwUr6A7wkzpIiQ_ROC8wQmhK8f2QdnQsbTl3rC7q-vfl3eVnc_b35cfrurrFIdVT13rW2dVa5GqTq1Xq2dkdjwlWqNQlcrbNq6Rqukc9rwtte2WdeaO6Ws1UKdsC977zSnxwUzDaPPuwAmYok3SN7UfVmwlAXle9TOKecZ3TDNfjTzdhB82N1j-P8eZeTzi31Zjbj-N_B6gAJUeyCbDQ4PaZljSfu28BmKaJfP</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Jackson, Emily R</creator><creator>Jared, Jason R</creator><creator>Piccolo, Jennifer K</creator><creator>Woo, Kaitlin M</creator><creator>Mably, Mary S</creator><creator>Reed, Michael P</creator><creator>Callander, Natalie S</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201907</creationdate><title>Granulocyte colony-stimulating factor utilization postautologous hematopoietic stem cell transplant in multiple myeloma patients: Does one size fit all?</title><author>Jackson, Emily R ; Jared, Jason R ; Piccolo, Jennifer K ; Woo, Kaitlin M ; Mably, Mary S ; Reed, Michael P ; Callander, Natalie S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-90f6c6fc3f4e2373dbdfa2e50b36a3ef43e5644ec32ff8a0698c5d480f33cc813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Emily R</creatorcontrib><creatorcontrib>Jared, Jason R</creatorcontrib><creatorcontrib>Piccolo, Jennifer K</creatorcontrib><creatorcontrib>Woo, Kaitlin M</creatorcontrib><creatorcontrib>Mably, Mary S</creatorcontrib><creatorcontrib>Reed, Michael P</creatorcontrib><creatorcontrib>Callander, Natalie S</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oncology pharmacy practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Emily R</au><au>Jared, Jason R</au><au>Piccolo, Jennifer K</au><au>Woo, Kaitlin M</au><au>Mably, Mary S</au><au>Reed, Michael P</au><au>Callander, Natalie S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulocyte colony-stimulating factor utilization postautologous hematopoietic stem cell transplant in multiple myeloma patients: Does one size fit all?</atitle><jtitle>Journal of oncology pharmacy practice</jtitle><addtitle>J Oncol Pharm Pract</addtitle><date>2019-07</date><risdate>2019</risdate><volume>25</volume><issue>5</issue><spage>1135</spage><epage>1141</epage><pages>1135-1141</pages><issn>1078-1552</issn><eissn>1477-092X</eissn><abstract>Purpose
To evaluate a single institution’s experience with granulocyte colony-stimulating factor after autologous hematopoietic stem cell transplant in myeloma patients to identify populations that benefit most from granulocyte colony-stimulating factor administration.
Methods
Retrospective chart reviews were conducted on patients 18+ years with multiple myeloma that underwent autologous hematopoietic stem cell transplant at UW Health from January 2012 to May 2016. Data collection included demographics, length of stay, time to engraftment, Eastern Cooperative Oncology Group performance status score, and hematopoietic cell transplantation-comorbidity index. The primary outcome was days from transplant to engraftment, defined as absolute neutrophil count > 500/mm3 for two consecutive days or absolute neutrophil count > 1000/mm3 once. A subset analysis was performed on patients whose date of engraftment was known.
Results
In total, 216 individual patients were included in the full cohort and 122 patients included in the subset analysis. Median time to engraftment between patients administered granulocyte colony-stimulating factor and the nongranulocyte colony-stimulating factor group was 12 versus 19 days (P < 0.001) in the full cohort and 12 versus 14 days (P < 0.001) in the subset analysis. The average length of stay posthematopoietic stem cell transplant in the granulocyte colony-stimulating factor group was 15 days versus 17 days in the nongranulocyte colony-stimulating factor group (P = 0.026) in the subset analysis. Additionally, no difference in time to engraftment was seen when stratified by age, Eastern Cooperative Oncology Group performance status score, or hematopoietic cell transplantation-comorbidity index.
Conclusion
Our study supports use of granulocyte colony-stimulating factor posthematopoietic stem cell transplant in myeloma patients to decrease time to engraftment and length of stay. Consideration should be given to utilization in all patients in this population posthematopoietic stem cell transplant. Further research is needed to identify the populations that benefit most from granulocyte colony-stimulating factor administration.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29890920</pmid><doi>10.1177/1078155218781888</doi><tpages>7</tpages></addata></record> |
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| title | Granulocyte colony-stimulating factor utilization postautologous hematopoietic stem cell transplant in multiple myeloma patients: Does one size fit all? |
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