Prediction of electro-anatomical substrate using APPLE score and biomarkers

Prediction of electro-anatomical substrate using APPLE score and biomarkers

Abstract Aims Low voltage areas (LVAs) represent advanced remodelling processes in left atrium in patients with atrial fibrillation (AF) and are associated with higher rates of arrhythmia recurrences. However, the prediction of LVA based on clinical parameters is understudied. Recently, we introduce...

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Veröffentlicht in:Europace (London, England) England), 2019-01, Vol.21 (1), p.54-59
Hauptverfasser: Kornej, Jelena, Büttner, Petra, Sommer, Philipp, Dagres, Nikolaos, Dinov, Borislav, Schumacher, Katja, Bollmann, Andreas, Hindricks, Gerhard
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials
Age Factors
Aged
Atrial Fibrillation - blood
Atrial Fibrillation - diagnosis
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
Atrial Function, Left
Atrial Natriuretic Factor - blood
Atrial Remodeling
Biomarkers - blood
Catheter Ablation
Decision Support Techniques
Female
Glomerular Filtration Rate
Heart Rate
Humans
Kidney - physiopathology
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Pilot Projects
Predictive Value of Tests
Pulmonary Veins - physiopathology
Pulmonary Veins - surgery
Recurrence
Risk Assessment
Risk Factors
Sex Factors
Time Factors
Treatment Outcome
Vascular Cell Adhesion Molecule-1 - blood
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Zusammenfassung:Abstract Aims Low voltage areas (LVAs) represent advanced remodelling processes in left atrium in patients with atrial fibrillation (AF) and are associated with higher rates of arrhythmia recurrences. However, the prediction of LVA based on clinical parameters is understudied. Recently, we introduced APPLE score to predict rhythm outcomes after catheter ablation. The aim of this study was to analyse (i) LVA prediction using APPLE score and (ii) differences in biomarker profiles according to APPLE score in AF patients. Methods and results Patients undergoing first AF ablation were included. The APPLE score (one point for Age >65 years, Persistent AF, imPaired eGFR 
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/euy120