Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver
This original study investigates the role of Opuntia ficus indica (cactus) cladodes extract against liver damage induced in male SWISS mice by an organophosphorous insecticide, the chlorpyrifos (CPF). Liver damage was evaluated by the measure of its weight and the quantification of some biochemical...
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| Veröffentlicht in: | Food and chemical toxicology 2008-02, Vol.46 (2), p.797-802 |
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| creator | Ncibi, Saida Ben Othman, Mahmoud Akacha, Amira Krifi, Mohamed Naceur Zourgui, Lazhar |
| description | This original study investigates the role of
Opuntia ficus indica (cactus) cladodes extract against liver damage induced in male SWISS mice by an organophosphorous insecticide, the chlorpyrifos (CPF). Liver damage was evaluated by the measure of its weight and the quantification of some biochemical parameters, such as alanine amino transferase (ALAT), aspartate amino transferase (ASAT), phosphatase alkaline (PAL), lactate dehydrogenase (LDH), cholesterol and albumin in serum by spectrophotometric techniques. The experimental approach lasted 48
h and consisted of 6 treatments of six mice each one; (1) control, (2) 10
mg/kg (b.w) CPF, (3) 10
mg/kg (b.w) CPF with 100
mg/kg (b.w) cactus, (4) 150
mg/kg (b.w)CPF, (5) 150
mg/kg (b.w) CPF with 1.5
g/kg cactus, (6) 1.5
g/kg cactus. Both chlorpyrifos and cactus were administrated orally via gavages.
Our results showed that CPF affects significantly all parameters studied. However, when this pesticide was administrated associated to cactus, we noticed a recovery of all their levels. In the other hand, cactus alone did not affect the studied parameters. These results allow us to conclude firstly that CPF is hepatotoxic and secondly that
Opuntia ficus indica stem extract protects the liver and decreases the toxicity induced by this organophosphorous pesticide. |
| doi_str_mv | 10.1016/j.fct.2007.08.047 |
| format | Article |
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Opuntia ficus indica (cactus) cladodes extract against liver damage induced in male SWISS mice by an organophosphorous insecticide, the chlorpyrifos (CPF). Liver damage was evaluated by the measure of its weight and the quantification of some biochemical parameters, such as alanine amino transferase (ALAT), aspartate amino transferase (ASAT), phosphatase alkaline (PAL), lactate dehydrogenase (LDH), cholesterol and albumin in serum by spectrophotometric techniques. The experimental approach lasted 48
h and consisted of 6 treatments of six mice each one; (1) control, (2) 10
mg/kg (b.w) CPF, (3) 10
mg/kg (b.w) CPF with 100
mg/kg (b.w) cactus, (4) 150
mg/kg (b.w)CPF, (5) 150
mg/kg (b.w) CPF with 1.5
g/kg cactus, (6) 1.5
g/kg cactus. Both chlorpyrifos and cactus were administrated orally via gavages.
Our results showed that CPF affects significantly all parameters studied. However, when this pesticide was administrated associated to cactus, we noticed a recovery of all their levels. In the other hand, cactus alone did not affect the studied parameters. These results allow us to conclude firstly that CPF is hepatotoxic and secondly that
Opuntia ficus indica stem extract protects the liver and decreases the toxicity induced by this organophosphorous pesticide.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2007.08.047</identifier><identifier>PMID: 17980473</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>animal models ; Animals ; Biochemical parameters ; Biological and medical sciences ; biomarkers ; Chemical and Drug Induced Liver Injury - enzymology ; Chemical and Drug Induced Liver Injury - prevention & control ; Chlorpyrifos ; Chlorpyrifos - antagonists & inhibitors ; Chlorpyrifos - toxicity ; dosage ; Dose-Response Relationship, Drug ; enzyme activity ; Ficus ; hepatoprotective effect ; hepatotoxicity ; Insecticides - antagonists & inhibitors ; Insecticides - toxicity ; Liver ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Mice ; Opuntia ; Opuntia ficus indica cladodes ; Opuntia ficus-indica ; oral administration ; Organ Size - drug effects ; Pesticides, fertilizers and other agrochemicals toxicology ; Phytotherapy ; plant extracts ; Plant Extracts - therapeutic use ; tissue weight ; Toxicology ; Weight</subject><ispartof>Food and chemical toxicology, 2008-02, Vol.46 (2), p.797-802</ispartof><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-1dbb417bc69f536399d19585c0579852b733c0b9f939b607528f7e12ac2309653</citedby><cites>FETCH-LOGICAL-c436t-1dbb417bc69f536399d19585c0579852b733c0b9f939b607528f7e12ac2309653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2007.08.047$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20068379$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17980473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ncibi, Saida</creatorcontrib><creatorcontrib>Ben Othman, Mahmoud</creatorcontrib><creatorcontrib>Akacha, Amira</creatorcontrib><creatorcontrib>Krifi, Mohamed Naceur</creatorcontrib><creatorcontrib>Zourgui, Lazhar</creatorcontrib><title>Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>This original study investigates the role of
Opuntia ficus indica (cactus) cladodes extract against liver damage induced in male SWISS mice by an organophosphorous insecticide, the chlorpyrifos (CPF). Liver damage was evaluated by the measure of its weight and the quantification of some biochemical parameters, such as alanine amino transferase (ALAT), aspartate amino transferase (ASAT), phosphatase alkaline (PAL), lactate dehydrogenase (LDH), cholesterol and albumin in serum by spectrophotometric techniques. The experimental approach lasted 48
h and consisted of 6 treatments of six mice each one; (1) control, (2) 10
mg/kg (b.w) CPF, (3) 10
mg/kg (b.w) CPF with 100
mg/kg (b.w) cactus, (4) 150
mg/kg (b.w)CPF, (5) 150
mg/kg (b.w) CPF with 1.5
g/kg cactus, (6) 1.5
g/kg cactus. Both chlorpyrifos and cactus were administrated orally via gavages.
Our results showed that CPF affects significantly all parameters studied. However, when this pesticide was administrated associated to cactus, we noticed a recovery of all their levels. In the other hand, cactus alone did not affect the studied parameters. These results allow us to conclude firstly that CPF is hepatotoxic and secondly that
Opuntia ficus indica stem extract protects the liver and decreases the toxicity induced by this organophosphorous pesticide.</description><subject>animal models</subject><subject>Animals</subject><subject>Biochemical parameters</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Chemical and Drug Induced Liver Injury - enzymology</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Chlorpyrifos</subject><subject>Chlorpyrifos - antagonists & inhibitors</subject><subject>Chlorpyrifos - toxicity</subject><subject>dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>enzyme activity</subject><subject>Ficus</subject><subject>hepatoprotective effect</subject><subject>hepatotoxicity</subject><subject>Insecticides - antagonists & inhibitors</subject><subject>Insecticides - toxicity</subject><subject>Liver</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Opuntia</subject><subject>Opuntia ficus indica cladodes</subject><subject>Opuntia ficus-indica</subject><subject>oral administration</subject><subject>Organ Size - drug effects</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - therapeutic use</subject><subject>tissue weight</subject><subject>Toxicology</subject><subject>Weight</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90btuFDEUgGELgciy8AA04CZ0M_FlfBMVisJFipQCIkrLc8ZevJrLYnsi8vbxalfQUbn5ztHRb4TeUtJSQuXVvg1QWkaIaoluSaeeoQ3VijeSC_ocbQhTupGGigv0Kuc9qZAq-RJdUGV05XyDft4d1rlEh0OENeM4DxEc9n9KclDwIS3FQ8nY7Vycc8Hwa1zS4THFsOSm4hX8gAc3uZ3Hy4ynCB6P8cGn1-hFcGP2b87vFt1_vvlx_bW5vfvy7frTbQMdl6WhQ993VPUgTRBccmMGaoQWQEQ9UbBecQ6kN8Fw00uiBNNBecocME6MFHyLPpz21lN_rz4XO8UMfhzd7Jc1W0ZEpzvNK6QnCGnJOflgDylOLj1aSuyxpt3bWtMea1qi7THPFr07L1_7yQ__Js75Krg8A5fBjSG5GWL-6-ouqbky1b0_ueAW63apmvvvjFBOiNaaUV3Fx5PwNdZD9MlmiH6ueWOqP2CHJf7n0CdLDJrr</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Ncibi, Saida</creator><creator>Ben Othman, Mahmoud</creator><creator>Akacha, Amira</creator><creator>Krifi, Mohamed Naceur</creator><creator>Zourgui, Lazhar</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20080201</creationdate><title>Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver</title><author>Ncibi, Saida ; Ben Othman, Mahmoud ; Akacha, Amira ; Krifi, Mohamed Naceur ; Zourgui, Lazhar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-1dbb417bc69f536399d19585c0579852b733c0b9f939b607528f7e12ac2309653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Biochemical parameters</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Chemical and Drug Induced Liver Injury - enzymology</topic><topic>Chemical and Drug Induced Liver Injury - prevention & control</topic><topic>Chlorpyrifos</topic><topic>Chlorpyrifos - antagonists & inhibitors</topic><topic>Chlorpyrifos - toxicity</topic><topic>dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>enzyme activity</topic><topic>Ficus</topic><topic>hepatoprotective effect</topic><topic>hepatotoxicity</topic><topic>Insecticides - antagonists & inhibitors</topic><topic>Insecticides - toxicity</topic><topic>Liver</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Opuntia</topic><topic>Opuntia ficus indica cladodes</topic><topic>Opuntia ficus-indica</topic><topic>oral administration</topic><topic>Organ Size - drug effects</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - therapeutic use</topic><topic>tissue weight</topic><topic>Toxicology</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ncibi, Saida</creatorcontrib><creatorcontrib>Ben Othman, Mahmoud</creatorcontrib><creatorcontrib>Akacha, Amira</creatorcontrib><creatorcontrib>Krifi, Mohamed Naceur</creatorcontrib><creatorcontrib>Zourgui, Lazhar</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ncibi, Saida</au><au>Ben Othman, Mahmoud</au><au>Akacha, Amira</au><au>Krifi, Mohamed Naceur</au><au>Zourgui, Lazhar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>46</volume><issue>2</issue><spage>797</spage><epage>802</epage><pages>797-802</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>This original study investigates the role of
Opuntia ficus indica (cactus) cladodes extract against liver damage induced in male SWISS mice by an organophosphorous insecticide, the chlorpyrifos (CPF). Liver damage was evaluated by the measure of its weight and the quantification of some biochemical parameters, such as alanine amino transferase (ALAT), aspartate amino transferase (ASAT), phosphatase alkaline (PAL), lactate dehydrogenase (LDH), cholesterol and albumin in serum by spectrophotometric techniques. The experimental approach lasted 48
h and consisted of 6 treatments of six mice each one; (1) control, (2) 10
mg/kg (b.w) CPF, (3) 10
mg/kg (b.w) CPF with 100
mg/kg (b.w) cactus, (4) 150
mg/kg (b.w)CPF, (5) 150
mg/kg (b.w) CPF with 1.5
g/kg cactus, (6) 1.5
g/kg cactus. Both chlorpyrifos and cactus were administrated orally via gavages.
Our results showed that CPF affects significantly all parameters studied. However, when this pesticide was administrated associated to cactus, we noticed a recovery of all their levels. In the other hand, cactus alone did not affect the studied parameters. These results allow us to conclude firstly that CPF is hepatotoxic and secondly that
Opuntia ficus indica stem extract protects the liver and decreases the toxicity induced by this organophosphorous pesticide.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>17980473</pmid><doi>10.1016/j.fct.2007.08.047</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2008-02, Vol.46 (2), p.797-802 |
| issn | 0278-6915 1873-6351 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | animal models Animals Biochemical parameters Biological and medical sciences biomarkers Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - prevention & control Chlorpyrifos Chlorpyrifos - antagonists & inhibitors Chlorpyrifos - toxicity dosage Dose-Response Relationship, Drug enzyme activity Ficus hepatoprotective effect hepatotoxicity Insecticides - antagonists & inhibitors Insecticides - toxicity Liver Male Medical sciences medicinal plants medicinal properties Mice Opuntia Opuntia ficus indica cladodes Opuntia ficus-indica oral administration Organ Size - drug effects Pesticides, fertilizers and other agrochemicals toxicology Phytotherapy plant extracts Plant Extracts - therapeutic use tissue weight Toxicology Weight |
| title | Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver |
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