Resistance to azolic compounds in clinical Trichophyton spp. strains
The increase of dermathophytosis in patients with poor therapeutic response leads us to study the antifungal susceptibility of 36 clinical isolates to itraconazole, ketoconazole and fluconazole by the E-test method. According to established parameters by the Clinical Laboratory Standards Institute,...
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Veröffentlicht in: | Revista iberoamericana de micología 2007-12, Vol.24 (4), p.320-322 |
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creator | Méndez-Tovar, Luis Javier Manzano-Gayosso, Patricia Velásquez-Hernández, Verónica Millan-Chiu, Blanca Hernández-Hernández, Francisca Mondragón-González, Rafael López-Martínez, Rubén |
description | The increase of dermathophytosis in patients with poor therapeutic response leads us to study the antifungal susceptibility of 36 clinical isolates to itraconazole, ketoconazole and fluconazole by the E-test method. According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. It is important to establish the antifungal susceptibility as part of the study procedures in patients with dermatophytosis and a poor antifungal response. |
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According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. 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According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. 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According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. It is important to establish the antifungal susceptibility as part of the study procedures in patients with dermatophytosis and a poor antifungal response.</abstract><cop>Spain</cop><pmid>18095769</pmid><tpages>3</tpages></addata></record> |
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subjects | Adult Antifungal Agents - pharmacology Cross Infection - microbiology Drug Resistance, Fungal Drug Resistance, Multiple, Fungal Epidermophyton - drug effects Epidermophyton - isolation & purification Female Fluconazole - pharmacology Humans Itraconazole - pharmacology Ketoconazole - pharmacology Male Mexico Microsporum - drug effects Microsporum - isolation & purification Onychomycosis - microbiology Tinea - microbiology Tinea Capitis - microbiology Tinea Pedis - microbiology Trichophyton Trichophyton - drug effects Trichophyton - isolation & purification Trichophyton rubrum |
title | Resistance to azolic compounds in clinical Trichophyton spp. strains |
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