Resistance to azolic compounds in clinical Trichophyton spp. strains

The increase of dermathophytosis in patients with poor therapeutic response leads us to study the antifungal susceptibility of 36 clinical isolates to itraconazole, ketoconazole and fluconazole by the E-test method. According to established parameters by the Clinical Laboratory Standards Institute,...

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Veröffentlicht in:Revista iberoamericana de micología 2007-12, Vol.24 (4), p.320-322
Hauptverfasser: Méndez-Tovar, Luis Javier, Manzano-Gayosso, Patricia, Velásquez-Hernández, Verónica, Millan-Chiu, Blanca, Hernández-Hernández, Francisca, Mondragón-González, Rafael, López-Martínez, Rubén
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container_title Revista iberoamericana de micología
container_volume 24
creator Méndez-Tovar, Luis Javier
Manzano-Gayosso, Patricia
Velásquez-Hernández, Verónica
Millan-Chiu, Blanca
Hernández-Hernández, Francisca
Mondragón-González, Rafael
López-Martínez, Rubén
description The increase of dermathophytosis in patients with poor therapeutic response leads us to study the antifungal susceptibility of 36 clinical isolates to itraconazole, ketoconazole and fluconazole by the E-test method. According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. It is important to establish the antifungal susceptibility as part of the study procedures in patients with dermatophytosis and a poor antifungal response.
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source MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Adult
Antifungal Agents - pharmacology
Cross Infection - microbiology
Drug Resistance, Fungal
Drug Resistance, Multiple, Fungal
Epidermophyton - drug effects
Epidermophyton - isolation & purification
Female
Fluconazole - pharmacology
Humans
Itraconazole - pharmacology
Ketoconazole - pharmacology
Male
Mexico
Microsporum - drug effects
Microsporum - isolation & purification
Onychomycosis - microbiology
Tinea - microbiology
Tinea Capitis - microbiology
Tinea Pedis - microbiology
Trichophyton
Trichophyton - drug effects
Trichophyton - isolation & purification
Trichophyton rubrum
title Resistance to azolic compounds in clinical Trichophyton spp. strains
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