Increased Frequency and Range of Sexual Behavior in a Patient with Parkinson's Disease After Use of Pramipexole: A Case Report
Several recent reports have linked the use of dopamine agonists (DAs) to a variety of compulsive behaviors in patients with Parkinson's disease (PD). These inappropriate behaviors may include pathological gambling, compulsive shopping, and hypersexuality. To report the case of a patient with in...
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| Veröffentlicht in: | Journal of sexual medicine 2009-04, Vol.6 (4), p.1177-1180 |
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| creator | Munhoz, Renato P. Fabiani, Giorgio Becker, Nilson Teive, Hélio A.G. |
| description | Several recent reports have linked the use of dopamine agonists (DAs) to a variety of compulsive behaviors in patients with Parkinson's disease (PD). These inappropriate behaviors may include pathological gambling, compulsive shopping, and hypersexuality.
To report the case of a patient with increased range of sexual behavior after use of pramipexole, a DA.
A 67-year-old man with a 7-year diagnosis of PD treated with levodopa and pramipexole presented with a dramatic change in sexual behavior after an increase in DA dose.
The patient, who historically was a very shy and conservative person, started to present increased frequency of sexual intercourse with his wife, during which he began speaking obscenities with an extreme preference for anal intercourse, preferences never requested before. After pramipexole was withdrawn, complete remission was observed with return to his usual sexual behavior.
Hypersexuality and paraphilias are complications not uncommonly found in patients with PD under dopaminergic treatment. Further studies are needed for the understanding of this complex complication, and particularly the most prevalent relationship between pathological hypersexuality and use of DAs. Munhoz RP, Fabiani G, Becker N, and Teive HAG. Increased frequency and range of sexual behavior in a patient with Parkinson's disease after use of pramipexole: A case report. J Sex Med **;**:**–**. |
| doi_str_mv | 10.1111/j.1743-6109.2008.00861.x |
| format | Article |
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To report the case of a patient with increased range of sexual behavior after use of pramipexole, a DA.
A 67-year-old man with a 7-year diagnosis of PD treated with levodopa and pramipexole presented with a dramatic change in sexual behavior after an increase in DA dose.
The patient, who historically was a very shy and conservative person, started to present increased frequency of sexual intercourse with his wife, during which he began speaking obscenities with an extreme preference for anal intercourse, preferences never requested before. After pramipexole was withdrawn, complete remission was observed with return to his usual sexual behavior.
Hypersexuality and paraphilias are complications not uncommonly found in patients with PD under dopaminergic treatment. Further studies are needed for the understanding of this complex complication, and particularly the most prevalent relationship between pathological hypersexuality and use of DAs. Munhoz RP, Fabiani G, Becker N, and Teive HAG. Increased frequency and range of sexual behavior in a patient with Parkinson's disease after use of pramipexole: A case report. J Sex Med **;**:**–**.</description><identifier>ISSN: 1743-6095</identifier><identifier>EISSN: 1743-6109</identifier><identifier>DOI: 10.1111/j.1743-6109.2008.00861.x</identifier><identifier>PMID: 18466265</identifier><language>eng</language><publisher>Malden, USA: Elsevier Inc</publisher><subject>Aged ; Anal Intercourse ; Benzothiazoles - administration & dosage ; Benzothiazoles - adverse effects ; Benzothiazoles - therapeutic use ; Dopamine Agonist ; Dopamine Agonists - administration & dosage ; Dopamine Agonists - adverse effects ; Dopamine Agonists - therapeutic use ; Humans ; Hypersexuality ; Male ; Paraphilic Disorders - chemically induced ; Parkinson Disease - drug therapy ; Parkinson's Disease ; Pramipexole ; Sexual Behavior - drug effects</subject><ispartof>Journal of sexual medicine, 2009-04, Vol.6 (4), p.1177-1180</ispartof><rights>2009 International Society for Sexual Medicine</rights><rights>2008 International Society for Sexual Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4941-ad3739d8893234295208f405de415eb5c27c758f56dbbf44cc932758567680d63</citedby><cites>FETCH-LOGICAL-c4941-ad3739d8893234295208f405de415eb5c27c758f56dbbf44cc932758567680d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1743-6109.2008.00861.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1743-6109.2008.00861.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18466265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Munhoz, Renato P.</creatorcontrib><creatorcontrib>Fabiani, Giorgio</creatorcontrib><creatorcontrib>Becker, Nilson</creatorcontrib><creatorcontrib>Teive, Hélio A.G.</creatorcontrib><title>Increased Frequency and Range of Sexual Behavior in a Patient with Parkinson's Disease After Use of Pramipexole: A Case Report</title><title>Journal of sexual medicine</title><addtitle>J Sex Med</addtitle><description>Several recent reports have linked the use of dopamine agonists (DAs) to a variety of compulsive behaviors in patients with Parkinson's disease (PD). These inappropriate behaviors may include pathological gambling, compulsive shopping, and hypersexuality.
To report the case of a patient with increased range of sexual behavior after use of pramipexole, a DA.
A 67-year-old man with a 7-year diagnosis of PD treated with levodopa and pramipexole presented with a dramatic change in sexual behavior after an increase in DA dose.
The patient, who historically was a very shy and conservative person, started to present increased frequency of sexual intercourse with his wife, during which he began speaking obscenities with an extreme preference for anal intercourse, preferences never requested before. After pramipexole was withdrawn, complete remission was observed with return to his usual sexual behavior.
Hypersexuality and paraphilias are complications not uncommonly found in patients with PD under dopaminergic treatment. Further studies are needed for the understanding of this complex complication, and particularly the most prevalent relationship between pathological hypersexuality and use of DAs. Munhoz RP, Fabiani G, Becker N, and Teive HAG. Increased frequency and range of sexual behavior in a patient with Parkinson's disease after use of pramipexole: A case report. J Sex Med **;**:**–**.</description><subject>Aged</subject><subject>Anal Intercourse</subject><subject>Benzothiazoles - administration & dosage</subject><subject>Benzothiazoles - adverse effects</subject><subject>Benzothiazoles - therapeutic use</subject><subject>Dopamine Agonist</subject><subject>Dopamine Agonists - administration & dosage</subject><subject>Dopamine Agonists - adverse effects</subject><subject>Dopamine Agonists - therapeutic use</subject><subject>Humans</subject><subject>Hypersexuality</subject><subject>Male</subject><subject>Paraphilic Disorders - chemically induced</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson's Disease</subject><subject>Pramipexole</subject><subject>Sexual Behavior - drug effects</subject><issn>1743-6095</issn><issn>1743-6109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhSMEog_4C8grWCXY8SMJYjMd-qIFSofSpeWxb6inGWewM21mw2_HaYayBEuWr-3vHOseJwkiOCNxvF1kpGA0FQRXWY5xmcUpSNY_SXYfL57-qXHFd5K9EBYY0zjy58kOKZkQueC7ya9Tpz2oAAYdefi5Bqc3SDmDLpX7Aait0Qz6tWrQAdyoO9t6ZB1S6EJ1FlyH7m13Ezf-1rrQujcBfbBhcEOTugOPrsKDxYVXS7uCvm3gHZqg6QBcwqr13YvkWa2aAC-3635ydXT4bXqSnn85Pp1OzlPNKkZSZWhBK1OWFc0pyyue47JmmBtghMOc67zQBS9rLsx8XjOmdQTjAReFKLERdD95PfqufBubDJ1c2qChaZSDdh1kjjkrOCURLEdQ-zYED7VcebtUfiMJlkP2ciGHWOUQsRyylw_Zyz5KX23fWM-XYP4Kt2FH4P0I3NsGNv9tLD_OPsUiytNRbkMH_aM8hi9FQQsurz8fS3Z2_X02PTuRXyN_MPIQg72z4GXQ8dM0GOtBd9K09t9N_QYnwrW0</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Munhoz, Renato P.</creator><creator>Fabiani, Giorgio</creator><creator>Becker, Nilson</creator><creator>Teive, Hélio A.G.</creator><general>Elsevier Inc</general><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>200904</creationdate><title>Increased Frequency and Range of Sexual Behavior in a Patient with Parkinson's Disease After Use of Pramipexole: A Case Report</title><author>Munhoz, Renato P. ; Fabiani, Giorgio ; Becker, Nilson ; Teive, Hélio A.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4941-ad3739d8893234295208f405de415eb5c27c758f56dbbf44cc932758567680d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Anal Intercourse</topic><topic>Benzothiazoles - administration & dosage</topic><topic>Benzothiazoles - adverse effects</topic><topic>Benzothiazoles - therapeutic use</topic><topic>Dopamine Agonist</topic><topic>Dopamine Agonists - administration & dosage</topic><topic>Dopamine Agonists - adverse effects</topic><topic>Dopamine Agonists - therapeutic use</topic><topic>Humans</topic><topic>Hypersexuality</topic><topic>Male</topic><topic>Paraphilic Disorders - chemically induced</topic><topic>Parkinson Disease - drug therapy</topic><topic>Parkinson's Disease</topic><topic>Pramipexole</topic><topic>Sexual Behavior - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Munhoz, Renato P.</creatorcontrib><creatorcontrib>Fabiani, Giorgio</creatorcontrib><creatorcontrib>Becker, Nilson</creatorcontrib><creatorcontrib>Teive, Hélio A.G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of sexual medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munhoz, Renato P.</au><au>Fabiani, Giorgio</au><au>Becker, Nilson</au><au>Teive, Hélio A.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Frequency and Range of Sexual Behavior in a Patient with Parkinson's Disease After Use of Pramipexole: A Case Report</atitle><jtitle>Journal of sexual medicine</jtitle><addtitle>J Sex Med</addtitle><date>2009-04</date><risdate>2009</risdate><volume>6</volume><issue>4</issue><spage>1177</spage><epage>1180</epage><pages>1177-1180</pages><issn>1743-6095</issn><eissn>1743-6109</eissn><abstract>Several recent reports have linked the use of dopamine agonists (DAs) to a variety of compulsive behaviors in patients with Parkinson's disease (PD). These inappropriate behaviors may include pathological gambling, compulsive shopping, and hypersexuality.
To report the case of a patient with increased range of sexual behavior after use of pramipexole, a DA.
A 67-year-old man with a 7-year diagnosis of PD treated with levodopa and pramipexole presented with a dramatic change in sexual behavior after an increase in DA dose.
The patient, who historically was a very shy and conservative person, started to present increased frequency of sexual intercourse with his wife, during which he began speaking obscenities with an extreme preference for anal intercourse, preferences never requested before. After pramipexole was withdrawn, complete remission was observed with return to his usual sexual behavior.
Hypersexuality and paraphilias are complications not uncommonly found in patients with PD under dopaminergic treatment. Further studies are needed for the understanding of this complex complication, and particularly the most prevalent relationship between pathological hypersexuality and use of DAs. Munhoz RP, Fabiani G, Becker N, and Teive HAG. Increased frequency and range of sexual behavior in a patient with Parkinson's disease after use of pramipexole: A case report. J Sex Med **;**:**–**.</abstract><cop>Malden, USA</cop><pub>Elsevier Inc</pub><pmid>18466265</pmid><doi>10.1111/j.1743-6109.2008.00861.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of sexual medicine, 2009-04, Vol.6 (4), p.1177-1180 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Anal Intercourse Benzothiazoles - administration & dosage Benzothiazoles - adverse effects Benzothiazoles - therapeutic use Dopamine Agonist Dopamine Agonists - administration & dosage Dopamine Agonists - adverse effects Dopamine Agonists - therapeutic use Humans Hypersexuality Male Paraphilic Disorders - chemically induced Parkinson Disease - drug therapy Parkinson's Disease Pramipexole Sexual Behavior - drug effects |
| title | Increased Frequency and Range of Sexual Behavior in a Patient with Parkinson's Disease After Use of Pramipexole: A Case Report |
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