Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model

The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes....

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Veröffentlicht in:	International journal of toxicology 2007-11, Vol.26 (6), p.525-532
Hauptverfasser:	Bulucu, F., Oktenli, C., Kenar, L., Koc, B., Ocal, R., Karadurmus, N., Inal, V., Yamanel, L., Sanisoglu, Y. S., Aydin, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - adverse effects Acetylcysteine - therapeutic use Animals Antioxidants - adverse effects Antioxidants - therapeutic use Catalase - blood Catalase - metabolism Copper - blood Deferoxamine - adverse effects Deferoxamine - therapeutic use Doxorubicin Drug Therapy, Combination Glutathione Peroxidase - blood Glutathione Peroxidase - metabolism Kidney - drug effects Kidney - metabolism Male Nephrotic Syndrome - chemically induced Nephrotic Syndrome - drug therapy Nephrotic Syndrome - metabolism Rats Rats, Sprague-Dawley Selenium - blood Superoxide Dismutase - blood Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism Zinc - blood Zinc - metabolism
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