Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model
The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes....
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| Veröffentlicht in: | International journal of toxicology 2007-11, Vol.26 (6), p.525-532 |
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| container_title | International journal of toxicology |
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| creator | Bulucu, F. Oktenli, C. Kenar, L. Koc, B. Ocal, R. Karadurmus, N. Inal, V. Yamanel, L. Sanisoglu, Y. S. Aydin, A. |
| description | The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes. Fifty-four male Sprague-Dawley rats were included the study. Equal volume of isotonic saline was injected to control rats. After DOX administration, the animals were divided into four experimental groups: (a) rats given only DOX; (b) rats treated with NAC; (c) rats treated with DFO; (d) rats treated with NAC plus DFO. The combination of N-acetylcysteine and DFO has no beneficial effect on reducing proteinuria in experimentally nephrotic rats, although both of these agents ameliorate the condition when administered separately. It seems likely that detrimental effects of NAC plus DFO could be secondary to its effects on erythrocyte selenium levels demonstrated here. Consequently, the results may propose caution to the use of antioxidant therapeutic strategies such as NAC plus DFO against nephropathy. |
| doi_str_mv | 10.1080/10915810701707403 |
| format | Article |
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S. ; Aydin, A.</creator><creatorcontrib>Bulucu, F. ; Oktenli, C. ; Kenar, L. ; Koc, B. ; Ocal, R. ; Karadurmus, N. ; Inal, V. ; Yamanel, L. ; Sanisoglu, Y. S. ; Aydin, A.</creatorcontrib><description>The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes. Fifty-four male Sprague-Dawley rats were included the study. Equal volume of isotonic saline was injected to control rats. After DOX administration, the animals were divided into four experimental groups: (a) rats given only DOX; (b) rats treated with NAC; (c) rats treated with DFO; (d) rats treated with NAC plus DFO. The combination of N-acetylcysteine and DFO has no beneficial effect on reducing proteinuria in experimentally nephrotic rats, although both of these agents ameliorate the condition when administered separately. It seems likely that detrimental effects of NAC plus DFO could be secondary to its effects on erythrocyte selenium levels demonstrated here. Consequently, the results may propose caution to the use of antioxidant therapeutic strategies such as NAC plus DFO against nephropathy.</description><identifier>ISSN: 1091-5818</identifier><identifier>EISSN: 1092-874X</identifier><identifier>DOI: 10.1080/10915810701707403</identifier><identifier>PMID: 18066968</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Acetylcysteine - adverse effects ; Acetylcysteine - therapeutic use ; Animals ; Antioxidants - adverse effects ; Antioxidants - therapeutic use ; Catalase - blood ; Catalase - metabolism ; Copper - blood ; Deferoxamine - adverse effects ; Deferoxamine - therapeutic use ; Doxorubicin ; Drug Therapy, Combination ; Glutathione Peroxidase - blood ; Glutathione Peroxidase - metabolism ; Kidney - drug effects ; Kidney - metabolism ; Male ; Nephrotic Syndrome - chemically induced ; Nephrotic Syndrome - drug therapy ; Nephrotic Syndrome - metabolism ; Rats ; Rats, Sprague-Dawley ; Selenium - blood ; Superoxide Dismutase - blood ; Superoxide Dismutase - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism ; Zinc - blood ; Zinc - metabolism</subject><ispartof>International journal of toxicology, 2007-11, Vol.26 (6), p.525-532</ispartof><rights>Copyright © American College of Toxicology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-51e1a751ce34b6ec95e3ae0893ea773cafffd89f1bfc49b8cf8eaaf1ffc1e9a43</citedby><cites>FETCH-LOGICAL-c412t-51e1a751ce34b6ec95e3ae0893ea773cafffd89f1bfc49b8cf8eaaf1ffc1e9a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1080/10915810701707403$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1080/10915810701707403$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21810,27915,27916,43612,43613</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18066968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bulucu, F.</creatorcontrib><creatorcontrib>Oktenli, C.</creatorcontrib><creatorcontrib>Kenar, L.</creatorcontrib><creatorcontrib>Koc, B.</creatorcontrib><creatorcontrib>Ocal, R.</creatorcontrib><creatorcontrib>Karadurmus, N.</creatorcontrib><creatorcontrib>Inal, V.</creatorcontrib><creatorcontrib>Yamanel, L.</creatorcontrib><creatorcontrib>Sanisoglu, Y. S.</creatorcontrib><creatorcontrib>Aydin, A.</creatorcontrib><title>Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model</title><title>International journal of toxicology</title><addtitle>SPIJT</addtitle><description>The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes. Fifty-four male Sprague-Dawley rats were included the study. Equal volume of isotonic saline was injected to control rats. After DOX administration, the animals were divided into four experimental groups: (a) rats given only DOX; (b) rats treated with NAC; (c) rats treated with DFO; (d) rats treated with NAC plus DFO. The combination of N-acetylcysteine and DFO has no beneficial effect on reducing proteinuria in experimentally nephrotic rats, although both of these agents ameliorate the condition when administered separately. It seems likely that detrimental effects of NAC plus DFO could be secondary to its effects on erythrocyte selenium levels demonstrated here. Consequently, the results may propose caution to the use of antioxidant therapeutic strategies such as NAC plus DFO against nephropathy.</description><subject>Acetylcysteine - adverse effects</subject><subject>Acetylcysteine - therapeutic use</subject><subject>Animals</subject><subject>Antioxidants - adverse effects</subject><subject>Antioxidants - therapeutic use</subject><subject>Catalase - blood</subject><subject>Catalase - metabolism</subject><subject>Copper - blood</subject><subject>Deferoxamine - adverse effects</subject><subject>Deferoxamine - therapeutic use</subject><subject>Doxorubicin</subject><subject>Drug Therapy, Combination</subject><subject>Glutathione Peroxidase - blood</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Nephrotic Syndrome - chemically induced</subject><subject>Nephrotic Syndrome - drug therapy</subject><subject>Nephrotic Syndrome - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Selenium - blood</subject><subject>Superoxide Dismutase - blood</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Zinc - blood</subject><subject>Zinc - metabolism</subject><issn>1091-5818</issn><issn>1092-874X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EoqXwA7ggn7ileJuXc6za8pCgIAESt8hx1pAqsYvtSM2_J6UVHJA47Wr1zWhnCDkHNgbG2RWwDGIOLGWQsjRi4QEZ9rdJwNPo7fB7h6AH-ICcOLdijCVpDMdkAJwlSZbwIbFz9LZqUHtR04VSKL2jRtFlMJXou1p2zmOlkT7VraNzdAqt2Yhme5qZpqi08JXRtNJUaLrYrPHHbYnrD2t8Jelzp0trGqQPpsT6lBwpUTs8288Reb1evMxug_vHm7vZ9D6QEUx8EAOC6N-VGEZFgjKLMRTIeBaiSNNQCqVUyTMFhZJRVnCpOAqhQCkJmIkoHJHLne_ams8Wnc-bykmsa6HRtC6fsDiK42gLwg6U1jhnUeXrPoSwXQ4s3xad_ym611zszduiwfJXsW-2B8Y7wIl3zFemtboP-4_jF65giO8</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Bulucu, F.</creator><creator>Oktenli, C.</creator><creator>Kenar, L.</creator><creator>Koc, B.</creator><creator>Ocal, R.</creator><creator>Karadurmus, N.</creator><creator>Inal, V.</creator><creator>Yamanel, L.</creator><creator>Sanisoglu, Y. S.</creator><creator>Aydin, A.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200711</creationdate><title>Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model</title><author>Bulucu, F. ; Oktenli, C. ; Kenar, L. ; Koc, B. ; Ocal, R. ; Karadurmus, N. ; Inal, V. ; Yamanel, L. ; Sanisoglu, Y. 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S.</au><au>Aydin, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model</atitle><jtitle>International journal of toxicology</jtitle><addtitle>SPIJT</addtitle><date>2007-11</date><risdate>2007</risdate><volume>26</volume><issue>6</issue><spage>525</spage><epage>532</epage><pages>525-532</pages><issn>1091-5818</issn><eissn>1092-874X</eissn><abstract>The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes. Fifty-four male Sprague-Dawley rats were included the study. Equal volume of isotonic saline was injected to control rats. After DOX administration, the animals were divided into four experimental groups: (a) rats given only DOX; (b) rats treated with NAC; (c) rats treated with DFO; (d) rats treated with NAC plus DFO. The combination of N-acetylcysteine and DFO has no beneficial effect on reducing proteinuria in experimentally nephrotic rats, although both of these agents ameliorate the condition when administered separately. It seems likely that detrimental effects of NAC plus DFO could be secondary to its effects on erythrocyte selenium levels demonstrated here. Consequently, the results may propose caution to the use of antioxidant therapeutic strategies such as NAC plus DFO against nephropathy.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>18066968</pmid><doi>10.1080/10915810701707403</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of toxicology, 2007-11, Vol.26 (6), p.525-532 |
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| subjects | Acetylcysteine - adverse effects Acetylcysteine - therapeutic use Animals Antioxidants - adverse effects Antioxidants - therapeutic use Catalase - blood Catalase - metabolism Copper - blood Deferoxamine - adverse effects Deferoxamine - therapeutic use Doxorubicin Drug Therapy, Combination Glutathione Peroxidase - blood Glutathione Peroxidase - metabolism Kidney - drug effects Kidney - metabolism Male Nephrotic Syndrome - chemically induced Nephrotic Syndrome - drug therapy Nephrotic Syndrome - metabolism Rats Rats, Sprague-Dawley Selenium - blood Superoxide Dismutase - blood Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism Zinc - blood Zinc - metabolism |
| title | Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model |
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