Bispyridinium Oximes As Antidotal Treatment of Cyclosarin Poisoning—In Vitro and In Vivo Testing

The mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents and less toxic pesticides, is based on the formation of irreversibly inhibited acetylcholinesterase, which causes cumulation of neuromediator acetylcholine in synaptic clefts and subsequent overstimula...

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Veröffentlicht in:	International journal of toxicology 2005-11, Vol.24 (6), p.399-402
Hauptverfasser:	Bartosova, Lucie, Kuca, Kamil, Jun, Daniel, Kunesova, Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidotes - pharmacology Antidotes - therapeutic use Atropine - therapeutic use Brain - drug effects Brain - enzymology Cholinesterase Inhibitors - toxicity Cholinesterase Reactivators - pharmacology Cholinesterase Reactivators - therapeutic use Dose-Response Relationship, Drug Drug Evaluation, Preclinical Enzyme Inhibitors - toxicity Female In Vitro Techniques Kinetics Lethal Dose 50 Mice Muscarinic Antagonists - therapeutic use Obidoxime Chloride - pharmacology Obidoxime Chloride - therapeutic use Organophosphorus Compounds - toxicity Oximes - pharmacology Oximes - therapeutic use Pyridinium Compounds - pharmacology Pyridinium Compounds - therapeutic use Rats Rats, Wistar
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