Tumor Necrosis Factor alpha Increases Neuronal Vulnerability to Excitotoxic Necrosis by Inducing Expression of the AMPA-Glutamate Receptor Subunit GluR1 via an Acid Sphingomyelinase- and NF- mu B-Dependent Mechanism

Acid sphingomyelinase (ASMase) and NF- mu B participate in tumor necrosis factor alpha (TNF alpha ) signal transduction. Mice in which the genes encoding ASMase or the p50 subunit of NF- mu B are disrupted have been reported to be less vulnerable than wild-type mice to focal brain ischemia. We now d...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Neurobiology of disease 2002-10, Vol.11 (1), p.199-213
Hauptverfasser:	Yu, Zaifang, Cheng, Guanjun, Wen, Xiaoming, Wu, Gary D, Lee, Wang-Tso, Pleasure, David
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!