Effects of scopolamine on morphine-induced conditioned place preference in mice
It is well known that the cholinergic system plays a crucial role in learning and memory. Psychopharmacological studies in humans and animals have shown that a systemic cholinergic blockade may induce deficits in learning and memory. Accumulated studies have indicated that learning and memory play a...
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| Veröffentlicht in: | Addiction biology 2007-09, Vol.12 (3-4), p.463-469 |
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| creator | Tan, Hua Liu, Ning Wilson, Fraser A W Ma, Yuanye |
| description | It is well known that the cholinergic system plays a crucial role in learning and memory. Psychopharmacological studies in humans and animals have shown that a systemic cholinergic blockade may induce deficits in learning and memory. Accumulated studies have indicated that learning and memory play an important role in drug addition. In the present study, in order to get a further understanding about the functions of the cholinergic system in drug-related learning and memory, we examined the effects of scopolamine (0.5, 1.0 and 2.0 mg/kg) on morphine-induced conditioned place preference (CPP). Two kinds of morphine exposure durations (4 days and 12 days) were used. The main finding was that all doses of scopolamine enhanced the extinction of morphine-induced CPP in mice treated with morphine for 12 days. However, in mice treated with morphine for 4 days, all doses of scopolamine did not inhibit morphine-induced CPP. The highest dose (2.0 mg/kg) of scopolamine even significantly delayed the extinction of morphine-induced CPP. Our results suggest that the effects of a systemic cholinergic blockade on morphine-induced CPP depend on the morphine exposure time. |
| doi_str_mv | 10.1111/j.1369-1600.2007.00062.x |
| format | Article |
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Psychopharmacological studies in humans and animals have shown that a systemic cholinergic blockade may induce deficits in learning and memory. Accumulated studies have indicated that learning and memory play an important role in drug addition. In the present study, in order to get a further understanding about the functions of the cholinergic system in drug-related learning and memory, we examined the effects of scopolamine (0.5, 1.0 and 2.0 mg/kg) on morphine-induced conditioned place preference (CPP). Two kinds of morphine exposure durations (4 days and 12 days) were used. The main finding was that all doses of scopolamine enhanced the extinction of morphine-induced CPP in mice treated with morphine for 12 days. However, in mice treated with morphine for 4 days, all doses of scopolamine did not inhibit morphine-induced CPP. The highest dose (2.0 mg/kg) of scopolamine even significantly delayed the extinction of morphine-induced CPP. Our results suggest that the effects of a systemic cholinergic blockade on morphine-induced CPP depend on the morphine exposure time.</description><identifier>ISSN: 1355-6215</identifier><identifier>DOI: 10.1111/j.1369-1600.2007.00062.x</identifier><identifier>PMID: 17678506</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Brain - drug effects ; Brain - physiopathology ; Conditioning, Classical - drug effects ; Conditioning, Classical - physiology ; Dose-Response Relationship, Drug ; Extinction, Psychological - drug effects ; Extinction, Psychological - physiology ; Male ; Memory - drug effects ; Memory - physiology ; Mice ; Mice, Inbred ICR ; Morphine ; Opioid-Related Disorders - physiopathology ; Opioid-Related Disorders - psychology ; Receptors, Cholinergic - drug effects ; Receptors, Cholinergic - physiology ; Scopolamine Hydrobromide - pharmacology ; Social Environment ; Time Factors</subject><ispartof>Addiction biology, 2007-09, Vol.12 (3-4), p.463-469</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17678506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Hua</creatorcontrib><creatorcontrib>Liu, Ning</creatorcontrib><creatorcontrib>Wilson, Fraser A W</creatorcontrib><creatorcontrib>Ma, Yuanye</creatorcontrib><title>Effects of scopolamine on morphine-induced conditioned place preference in mice</title><title>Addiction biology</title><addtitle>Addict Biol</addtitle><description>It is well known that the cholinergic system plays a crucial role in learning and memory. Psychopharmacological studies in humans and animals have shown that a systemic cholinergic blockade may induce deficits in learning and memory. Accumulated studies have indicated that learning and memory play an important role in drug addition. In the present study, in order to get a further understanding about the functions of the cholinergic system in drug-related learning and memory, we examined the effects of scopolamine (0.5, 1.0 and 2.0 mg/kg) on morphine-induced conditioned place preference (CPP). Two kinds of morphine exposure durations (4 days and 12 days) were used. The main finding was that all doses of scopolamine enhanced the extinction of morphine-induced CPP in mice treated with morphine for 12 days. However, in mice treated with morphine for 4 days, all doses of scopolamine did not inhibit morphine-induced CPP. The highest dose (2.0 mg/kg) of scopolamine even significantly delayed the extinction of morphine-induced CPP. Our results suggest that the effects of a systemic cholinergic blockade on morphine-induced CPP depend on the morphine exposure time.</description><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - physiopathology</subject><subject>Conditioning, Classical - drug effects</subject><subject>Conditioning, Classical - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Extinction, Psychological - drug effects</subject><subject>Extinction, Psychological - physiology</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Morphine</subject><subject>Opioid-Related Disorders - physiopathology</subject><subject>Opioid-Related Disorders - psychology</subject><subject>Receptors, Cholinergic - drug effects</subject><subject>Receptors, Cholinergic - physiology</subject><subject>Scopolamine Hydrobromide - pharmacology</subject><subject>Social Environment</subject><subject>Time Factors</subject><issn>1355-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kD9PwzAUxD2AaCl8BZSJLeHZiV-SEVXlj1SpC8yRYz-Dq8QOcSPBt8cS5Zb7DXc3HGMZh4InPRwLXmKbcwQoBEBdAACK4vuCrXkpZY6CyxW7jvEIwEUtyyu24jXWjQRcs8POWtKnmAWbRR2mMKjRecqCz8YwT5-Jc-fNoslkOnjjTi74xNOgNGXTTJZm8gldKjhNN-zSqiHS7dk37P1p97Z9yfeH59ft4z7_EChPuUCsBElTC9NWxtqm78sGJecaJRqF0rYaq-Rt35jWWCFUK2SFoukNB5Tlht3_7U5z-FoonrrRRU3DoDyFJXYCZMWhqVLw7hxc-pFMN81uVPNP939B-QusfV2R</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Tan, Hua</creator><creator>Liu, Ning</creator><creator>Wilson, Fraser A W</creator><creator>Ma, Yuanye</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20070901</creationdate><title>Effects of scopolamine on morphine-induced conditioned place preference in mice</title><author>Tan, Hua ; Liu, Ning ; Wilson, Fraser A W ; Ma, Yuanye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g265t-26642e5d72d94dff8bb386511c656da65f9c64a659b8d9df22a9254628bd10653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - physiopathology</topic><topic>Conditioning, Classical - drug effects</topic><topic>Conditioning, Classical - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Extinction, Psychological - drug effects</topic><topic>Extinction, Psychological - physiology</topic><topic>Male</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Morphine</topic><topic>Opioid-Related Disorders - physiopathology</topic><topic>Opioid-Related Disorders - psychology</topic><topic>Receptors, Cholinergic - drug effects</topic><topic>Receptors, Cholinergic - physiology</topic><topic>Scopolamine Hydrobromide - pharmacology</topic><topic>Social Environment</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Hua</creatorcontrib><creatorcontrib>Liu, Ning</creatorcontrib><creatorcontrib>Wilson, Fraser A W</creatorcontrib><creatorcontrib>Ma, Yuanye</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Addiction biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Hua</au><au>Liu, Ning</au><au>Wilson, Fraser A W</au><au>Ma, Yuanye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of scopolamine on morphine-induced conditioned place preference in mice</atitle><jtitle>Addiction biology</jtitle><addtitle>Addict Biol</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>12</volume><issue>3-4</issue><spage>463</spage><epage>469</epage><pages>463-469</pages><issn>1355-6215</issn><abstract>It is well known that the cholinergic system plays a crucial role in learning and memory. Psychopharmacological studies in humans and animals have shown that a systemic cholinergic blockade may induce deficits in learning and memory. Accumulated studies have indicated that learning and memory play an important role in drug addition. In the present study, in order to get a further understanding about the functions of the cholinergic system in drug-related learning and memory, we examined the effects of scopolamine (0.5, 1.0 and 2.0 mg/kg) on morphine-induced conditioned place preference (CPP). Two kinds of morphine exposure durations (4 days and 12 days) were used. The main finding was that all doses of scopolamine enhanced the extinction of morphine-induced CPP in mice treated with morphine for 12 days. However, in mice treated with morphine for 4 days, all doses of scopolamine did not inhibit morphine-induced CPP. The highest dose (2.0 mg/kg) of scopolamine even significantly delayed the extinction of morphine-induced CPP. 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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Brain - drug effects Brain - physiopathology Conditioning, Classical - drug effects Conditioning, Classical - physiology Dose-Response Relationship, Drug Extinction, Psychological - drug effects Extinction, Psychological - physiology Male Memory - drug effects Memory - physiology Mice Mice, Inbred ICR Morphine Opioid-Related Disorders - physiopathology Opioid-Related Disorders - psychology Receptors, Cholinergic - drug effects Receptors, Cholinergic - physiology Scopolamine Hydrobromide - pharmacology Social Environment Time Factors |
| title | Effects of scopolamine on morphine-induced conditioned place preference in mice |
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