Simultaneous determination of (fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography–tandem mass spectrometry
The ultra performance liquid chromatography–tandem mass spectrometry (UPLC) method had been developed for 22 (fluoro)quinolone(QNs) antibacterials in milk with multiple reaction monitoring (MRM) as acquisition mode. The analytes were extracted from the sample using Mcllvaine buffer by ultrasonic bat...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2009-02, Vol.49 (2), p.367-374 |
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| creator | Zhang, Hong Ren, Yiping Bao, Xiaoli |
| description | The ultra performance liquid chromatography–tandem mass spectrometry (UPLC) method had been developed for 22 (fluoro)quinolone(QNs) antibacterials in milk with multiple reaction monitoring (MRM) as acquisition mode. The analytes were extracted from the sample using Mcllvaine buffer by ultrasonic bath, and purified by solid-phase extraction (SPE) cartridge. The residue were dried under nitrogen and dissolved in mobile phase before UPLC–MS/MS final analysis. The calibration curve of six concentrations for 22 QNs showed good linearity and the good correlation coefficients (
r
≥
0.9851) were achieved. The limit range of quantification was 0.008–0.339
μg/kg. The recovery range was 63.1–94.6% except flumequine, nalidixic acid and nadifloxacin. The method was precise: the relative standard deviations of the method for milk were not more than 13.12%. The accuracies and sensitivity of the method were good for simultaneous determination of 22 QNs. |
| doi_str_mv | 10.1016/j.jpba.2008.10.043 |
| format | Article |
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r
≥
0.9851) were achieved. The limit range of quantification was 0.008–0.339
μg/kg. The recovery range was 63.1–94.6% except flumequine, nalidixic acid and nadifloxacin. The method was precise: the relative standard deviations of the method for milk were not more than 13.12%. The accuracies and sensitivity of the method were good for simultaneous determination of 22 QNs.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2008.10.043</identifier><identifier>PMID: 19162423</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Anti-Bacterial Agents - analysis ; Biological and medical sciences ; Bovine milk ; Buffers ; Calibration ; Cattle ; Chromatography, Liquid - instrumentation ; Chromatography, Liquid - methods ; Drug Residues - analysis ; Female ; Fluoroquinolones - analysis ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Medical sciences ; Milk - chemistry ; Pharmacology. Drug treatments ; Quinolone antibacterials ; Sensitivity and Specificity ; Solid Phase Extraction ; Spectrometry, Mass, Electrospray Ionization - methods ; Tandem Mass Spectrometry - methods ; Ultrasonics ; UPLC–MS/MS</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2009-02, Vol.49 (2), p.367-374</ispartof><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-6534e7134e710736fd9e883a7a3a9419171810756bc4fe3c62698a0cc5ab031b3</citedby><cites>FETCH-LOGICAL-c415t-6534e7134e710736fd9e883a7a3a9419171810756bc4fe3c62698a0cc5ab031b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpba.2008.10.043$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21265849$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19162423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Ren, Yiping</creatorcontrib><creatorcontrib>Bao, Xiaoli</creatorcontrib><title>Simultaneous determination of (fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography–tandem mass spectrometry</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>The ultra performance liquid chromatography–tandem mass spectrometry (UPLC) method had been developed for 22 (fluoro)quinolone(QNs) antibacterials in milk with multiple reaction monitoring (MRM) as acquisition mode. The analytes were extracted from the sample using Mcllvaine buffer by ultrasonic bath, and purified by solid-phase extraction (SPE) cartridge. The residue were dried under nitrogen and dissolved in mobile phase before UPLC–MS/MS final analysis. The calibration curve of six concentrations for 22 QNs showed good linearity and the good correlation coefficients (
r
≥
0.9851) were achieved. The limit range of quantification was 0.008–0.339
μg/kg. The recovery range was 63.1–94.6% except flumequine, nalidixic acid and nadifloxacin. The method was precise: the relative standard deviations of the method for milk were not more than 13.12%. The accuracies and sensitivity of the method were good for simultaneous determination of 22 QNs.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Biological and medical sciences</subject><subject>Bovine milk</subject><subject>Buffers</subject><subject>Calibration</subject><subject>Cattle</subject><subject>Chromatography, Liquid - instrumentation</subject><subject>Chromatography, Liquid - methods</subject><subject>Drug Residues - analysis</subject><subject>Female</subject><subject>Fluoroquinolones - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Milk - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinolone antibacterials</subject><subject>Sensitivity and Specificity</subject><subject>Solid Phase Extraction</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Ultrasonics</subject><subject>UPLC–MS/MS</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQhS0EYpqBC7BA3oBgkcaOnT-JDRrxJ43EApDYWY5TmakmtjN2MlLvuAMX4GychGq6BTs2tlT1-bnqPcYeS7GVQtYvd9vd3NttKURLha3Q6g7byLZRRVnrr3fZRjRKFo1oqzP2IOedEKKSnb7PzmQn61KXasN-fkK_TosNENfMB1ggeQx2wRh4HPnzcVpjii9uVgxxigEyt2HB3joC0U6ZJ8g4rFTHwPt4iwG4x-kbXzOGK07SyfIZ0hiTt8EBn5C0Bu6uU_R2iVfJztf7X99_0AgDeO5tzjzP4Bbqw5L2D9m9kf6BR6f7nH15--bzxfvi8uO7DxevLwunZbUUdaU0NPLPQWvX49BB2yrbWGU7Tfs2sqVGVfdOj6BcXdZda4Vzle2Fkr06Z8-OunOKN7TPYjxmB9N0tMaUolIdWUZgeQRdijknGM2c0Nu0N1KYQy5mZw65mEMuhxrlQo-enNTX3sPw78kpCAKengCbnZ3GRGZh_suVsqyrVnfEvTpyQF7cIiSTHQIZO2Ai08wQ8X9z_AbA-bGF</recordid><startdate>20090220</startdate><enddate>20090220</enddate><creator>Zhang, Hong</creator><creator>Ren, Yiping</creator><creator>Bao, Xiaoli</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20090220</creationdate><title>Simultaneous determination of (fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography–tandem mass spectrometry</title><author>Zhang, Hong ; Ren, Yiping ; Bao, Xiaoli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-6534e7134e710736fd9e883a7a3a9419171810756bc4fe3c62698a0cc5ab031b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>Biological and medical sciences</topic><topic>Bovine milk</topic><topic>Buffers</topic><topic>Calibration</topic><topic>Cattle</topic><topic>Chromatography, Liquid - instrumentation</topic><topic>Chromatography, Liquid - methods</topic><topic>Drug Residues - analysis</topic><topic>Female</topic><topic>Fluoroquinolones - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Milk - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinolone antibacterials</topic><topic>Sensitivity and Specificity</topic><topic>Solid Phase Extraction</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Ultrasonics</topic><topic>UPLC–MS/MS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Ren, Yiping</creatorcontrib><creatorcontrib>Bao, Xiaoli</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Hong</au><au>Ren, Yiping</au><au>Bao, Xiaoli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous determination of (fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography–tandem mass spectrometry</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2009-02-20</date><risdate>2009</risdate><volume>49</volume><issue>2</issue><spage>367</spage><epage>374</epage><pages>367-374</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>The ultra performance liquid chromatography–tandem mass spectrometry (UPLC) method had been developed for 22 (fluoro)quinolone(QNs) antibacterials in milk with multiple reaction monitoring (MRM) as acquisition mode. The analytes were extracted from the sample using Mcllvaine buffer by ultrasonic bath, and purified by solid-phase extraction (SPE) cartridge. The residue were dried under nitrogen and dissolved in mobile phase before UPLC–MS/MS final analysis. The calibration curve of six concentrations for 22 QNs showed good linearity and the good correlation coefficients (
r
≥
0.9851) were achieved. The limit range of quantification was 0.008–0.339
μg/kg. The recovery range was 63.1–94.6% except flumequine, nalidixic acid and nadifloxacin. The method was precise: the relative standard deviations of the method for milk were not more than 13.12%. The accuracies and sensitivity of the method were good for simultaneous determination of 22 QNs.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19162423</pmid><doi>10.1016/j.jpba.2008.10.043</doi><tpages>8</tpages></addata></record> |
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| subjects | Analysis Analytical, structural and metabolic biochemistry Animals Anti-Bacterial Agents - analysis Biological and medical sciences Bovine milk Buffers Calibration Cattle Chromatography, Liquid - instrumentation Chromatography, Liquid - methods Drug Residues - analysis Female Fluoroquinolones - analysis Fundamental and applied biological sciences. Psychology General pharmacology Medical sciences Milk - chemistry Pharmacology. Drug treatments Quinolone antibacterials Sensitivity and Specificity Solid Phase Extraction Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods Ultrasonics UPLC–MS/MS |
| title | Simultaneous determination of (fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography–tandem mass spectrometry |
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