Effect of interleukin 13 on bronchial hyperresponsiveness and the bronchoprotective effect of β-adrenergic bronchodilators and corticosteroids

Background Fluticasone affects airway bronchial hyperresponsiveness (BHR) and enhances bronchodilation and bronchoprotection induced by β-adrenergic agonists. Interleukin 13 (IL-13), however, induces BHR. Objective To test the hypotheses that fluticasone inhibits BHR after either allergen sensitizat...

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Veröffentlicht in:	Annals of allergy, asthma, & immunology asthma, & immunology, 2009-03, Vol.102 (3), p.190-197
Hauptverfasser:	Townley, Robert G., MD, Gendapodi, Pradeep R., DVM, Qutna, Nidal, MD, Evans, Joseph, BS, Romero, Francisco A., MS, Abel, Peter, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - pharmacology Adrenergic beta-Agonists - pharmacology Albuterol - administration & dosage Albuterol - analogs & derivatives Albuterol - pharmacology Allergy and Immunology Androstadienes - administration & dosage Androstadienes - pharmacology Animals Biological and medical sciences Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - physiopathology Bronchial Hyperreactivity - prevention & control Bronchial Provocation Tests Bronchoconstriction - drug effects Bronchodilator Agents - pharmacology Dermatology Drug Combinations Female Fluticasone Fluticasone-Salmeterol Drug Combination Fundamental and applied biological sciences. Psychology Fundamental immunology Interleukin-13 - administration & dosage Interleukin-13 - antagonists & inhibitors Interleukin-13 - pharmacology Interleukin-13 Receptor alpha2 Subunit - administration & dosage Medical sciences Methacholine Chloride - pharmacology Mice Mice, Inbred BALB C Ovalbumin - immunology Salmeterol Xinafoate Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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