Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes

Steroidogenic factor SF-1, a constitutively active nuclear hormone receptor, is essential to the development of adrenal and gonadal glands and acts as a shaping factor of sexual determination and differentiation. Its effects are exerted primarily through the control of the synthesis of steroid hormo...

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Veröffentlicht in:	Molecular pharmacology 2008-03, Vol.73 (3), p.900-908
Hauptverfasser:	Del Tredici, Andria L., Andersen, Carsten B., Currier, Erika A., Ohrmund, Steven R., Fairbain, Luke C., Lund, Birgitte W., Nash, Norman, Olsson, Roger, Piu, Fabrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - pathology Animals Carcinoma - pathology Cell Proliferation - drug effects Cholesterol Side-Chain Cleavage Enzyme - genetics Cholesterol Side-Chain Cleavage Enzyme - metabolism Cyclic AMP - pharmacology Drug Evaluation, Preclinical - methods Genes, Reporter Humans Inhibitory Concentration 50 Ligands Luciferases - metabolism Mice Mutation NIH 3T3 Cells Phenols - pharmacology RNA, Messenger - metabolism Steroidogenic Factor 1 - agonists Steroidogenic Factor 1 - chemical synthesis Steroidogenic Factor 1 - chemistry Steroidogenic Factor 1 - genetics Transcription, Genetic Transcriptional Activation Transfection Tumor Cells, Cultured
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