Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce A beta 42 in response to tunicamycin

Many patients affected by early onset familial Alzheimer's disease (FAD), carry mutations in the presenilin 1 (PS1) gene. Since it has been suggested that FAD-linked PS1 mutations impair the unfolded protein response (UPR) due to endoplasmic reticulum (ER) stress, we analyzed the UPR and amyloi...

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Veröffentlicht in:	Neurobiology of disease 2004-03, Vol.15 (2), p.380-386
Hauptverfasser:	Piccini, Alessandra, Fassio, Anna, Pasqualetto, Elena, Vitali, Antonella, Borghi, Roberta, Palmieri, Daniela, Nacmias, Benedetta, Sorbi, Sandro, Sitia, Roberto, Tabaton, Massimo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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