Chemotherapy-Induced Mucositis Is Associated with Changes in Proteolytic Pathways

Mucositis, a common toxic side effect of chemotherapy, is characterized by an arrest of cell proliferation and a loss of gut barrier function, which may cause treatment reduction or withdrawal. Gut integrity depends on nutritional and metabolic factors, including the balance between protein synthesi...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2008-02, Vol.233 (2), p.219-228
Hauptverfasser:	Leblond, Jonathan, Le Pessot, Florence, Hubert-Buron, Aurélie, Duclos, Célia, Vuichoud, Jacques, Faure, Magali, Breuillé, Denis, Déchelotte, Pierre, Coëffier, Moïse
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Cell Proliferation Cytokines - metabolism Eating - drug effects Glutathione - metabolism Intestinal Absorption - drug effects Jejunum - metabolism Male Methotrexate - pharmacology Mucositis - chemically induced Mucositis - enzymology Mucositis - pathology Peptide Hydrolases - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects
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