A clinical study of HMME-PDT therapy in Chinese pediatric patients with port-wine stain
To report our observations from a trial of the effectiveness and safety of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating Chinese Pediatric patients port-wine stains (PWS). From October 2017 to December 2017, the study recruited 82 patients of PWS with negative HMME ski...
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| Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2018-09, Vol.23, p.102-105 |
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| container_title | Photodiagnosis and photodynamic therapy |
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| creator | Li-qiang, Gan Hua, Wang Si-li, Ni Chun-hua, Tan |
| description | To report our observations from a trial of the effectiveness and safety of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating Chinese Pediatric patients port-wine stains (PWS).
From October 2017 to December 2017, the study recruited 82 patients of PWS with negative HMME skin test results. The patients received an intravenous injection of 5 mg/kg HMME and the affected areas were exposed to 532 nm LED green light, with the irradiation power density between 80–85 mW/cm2. Each light spot was irradiated for 20–25 min. After two treatments, the clinical efficacy and posttreatment reactions at each treated area were observed.
The patient age between 1 and 14 years old. 24 of the 82 cases were cured (29.27%) after two HMME-PDT treatment, 34 cases indicates a good efficacy (41.46%), 16 cases showed alleviation (19.51%), while 8 cases displayed no efficacy (9.76%). Pain was observed during treatment, and post-treatment edema was observed at the treated areas. No other obvious systematic adverse reaction were reported.
HMME-PDT is an effective and safe treatment for pediatric patients with PWS. |
| doi_str_mv | 10.1016/j.pdpdt.2018.06.006 |
| format | Article |
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From October 2017 to December 2017, the study recruited 82 patients of PWS with negative HMME skin test results. The patients received an intravenous injection of 5 mg/kg HMME and the affected areas were exposed to 532 nm LED green light, with the irradiation power density between 80–85 mW/cm2. Each light spot was irradiated for 20–25 min. After two treatments, the clinical efficacy and posttreatment reactions at each treated area were observed.
The patient age between 1 and 14 years old. 24 of the 82 cases were cured (29.27%) after two HMME-PDT treatment, 34 cases indicates a good efficacy (41.46%), 16 cases showed alleviation (19.51%), while 8 cases displayed no efficacy (9.76%). Pain was observed during treatment, and post-treatment edema was observed at the treated areas. No other obvious systematic adverse reaction were reported.
HMME-PDT is an effective and safe treatment for pediatric patients with PWS.</description><identifier>ISSN: 1572-1000</identifier><identifier>EISSN: 1873-1597</identifier><identifier>DOI: 10.1016/j.pdpdt.2018.06.006</identifier><identifier>PMID: 29885812</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Child ; Child, Preschool ; Chinese pediatric patients ; Female ; Hematoporphyrin monomethyl ether ; Hematoporphyrins - administration & dosage ; Humans ; Infant ; Male ; Photochemotherapy - adverse effects ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - administration & dosage ; Port-wine stain ; Port-Wine Stain - drug therapy</subject><ispartof>Photodiagnosis and photodynamic therapy, 2018-09, Vol.23, p.102-105</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-b213ae6a0d482d40d44bcf7c86b342f04ec8123761f609ea37c16ac820ed2c763</citedby><cites>FETCH-LOGICAL-c359t-b213ae6a0d482d40d44bcf7c86b342f04ec8123761f609ea37c16ac820ed2c763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pdpdt.2018.06.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29885812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li-qiang, Gan</creatorcontrib><creatorcontrib>Hua, Wang</creatorcontrib><creatorcontrib>Si-li, Ni</creatorcontrib><creatorcontrib>Chun-hua, Tan</creatorcontrib><title>A clinical study of HMME-PDT therapy in Chinese pediatric patients with port-wine stain</title><title>Photodiagnosis and photodynamic therapy</title><addtitle>Photodiagnosis Photodyn Ther</addtitle><description>To report our observations from a trial of the effectiveness and safety of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating Chinese Pediatric patients port-wine stains (PWS).
From October 2017 to December 2017, the study recruited 82 patients of PWS with negative HMME skin test results. The patients received an intravenous injection of 5 mg/kg HMME and the affected areas were exposed to 532 nm LED green light, with the irradiation power density between 80–85 mW/cm2. Each light spot was irradiated for 20–25 min. After two treatments, the clinical efficacy and posttreatment reactions at each treated area were observed.
The patient age between 1 and 14 years old. 24 of the 82 cases were cured (29.27%) after two HMME-PDT treatment, 34 cases indicates a good efficacy (41.46%), 16 cases showed alleviation (19.51%), while 8 cases displayed no efficacy (9.76%). Pain was observed during treatment, and post-treatment edema was observed at the treated areas. No other obvious systematic adverse reaction were reported.
HMME-PDT is an effective and safe treatment for pediatric patients with PWS.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chinese pediatric patients</subject><subject>Female</subject><subject>Hematoporphyrin monomethyl ether</subject><subject>Hematoporphyrins - administration & dosage</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Photochemotherapy - adverse effects</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - administration & dosage</subject><subject>Port-wine stain</subject><subject>Port-Wine Stain - drug therapy</subject><issn>1572-1000</issn><issn>1873-1597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi1UBFvgF1SqfOwl6dhOHOfQw2pLoRIIDiCOlteeaL3KJqntgPbfY1jaY08zh-edj4eQLwxKBkx-35aTm1wqOTBVgiwB5BFZMNWIgtVt8yn3dcMLBgCn5HOMWwBRtVCdkFPeKlUrxhfkaUlt7wdvTU9jmt2ejh29vr29LO5_PtC0wWCmPfUDXW38gBHphM6bFLylk0kehxTpi08bOo0hFS-ZyWOMH87JcWf6iBcf9Yw8_rp8WF0XN3dXv1fLm8KKuk3FmjNhUBpwleKuyqVa266xSq5FxTuo0OYzRSNZJ6FFIxrLpLGKAzpuGynOyLfD3CmMf2aMSe98tNj3ZsBxjppDLbgSNbQZFQfUhjHGgJ2egt-ZsNcM9JtRvdXvRvWbUQ1SZ6M59fVjwbzeofuX-aswAz8OAOY3nz0GHW32YrOngDZpN_r_LngFKHKHjw</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Li-qiang, Gan</creator><creator>Hua, Wang</creator><creator>Si-li, Ni</creator><creator>Chun-hua, Tan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201809</creationdate><title>A clinical study of HMME-PDT therapy in Chinese pediatric patients with port-wine stain</title><author>Li-qiang, Gan ; Hua, Wang ; Si-li, Ni ; Chun-hua, Tan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-b213ae6a0d482d40d44bcf7c86b342f04ec8123761f609ea37c16ac820ed2c763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chinese pediatric patients</topic><topic>Female</topic><topic>Hematoporphyrin monomethyl ether</topic><topic>Hematoporphyrins - administration & dosage</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Photochemotherapy - adverse effects</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - administration & dosage</topic><topic>Port-wine stain</topic><topic>Port-Wine Stain - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li-qiang, Gan</creatorcontrib><creatorcontrib>Hua, Wang</creatorcontrib><creatorcontrib>Si-li, Ni</creatorcontrib><creatorcontrib>Chun-hua, Tan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li-qiang, Gan</au><au>Hua, Wang</au><au>Si-li, Ni</au><au>Chun-hua, Tan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A clinical study of HMME-PDT therapy in Chinese pediatric patients with port-wine stain</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2018-09</date><risdate>2018</risdate><volume>23</volume><spage>102</spage><epage>105</epage><pages>102-105</pages><issn>1572-1000</issn><eissn>1873-1597</eissn><abstract>To report our observations from a trial of the effectiveness and safety of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating Chinese Pediatric patients port-wine stains (PWS).
From October 2017 to December 2017, the study recruited 82 patients of PWS with negative HMME skin test results. The patients received an intravenous injection of 5 mg/kg HMME and the affected areas were exposed to 532 nm LED green light, with the irradiation power density between 80–85 mW/cm2. Each light spot was irradiated for 20–25 min. After two treatments, the clinical efficacy and posttreatment reactions at each treated area were observed.
The patient age between 1 and 14 years old. 24 of the 82 cases were cured (29.27%) after two HMME-PDT treatment, 34 cases indicates a good efficacy (41.46%), 16 cases showed alleviation (19.51%), while 8 cases displayed no efficacy (9.76%). Pain was observed during treatment, and post-treatment edema was observed at the treated areas. No other obvious systematic adverse reaction were reported.
HMME-PDT is an effective and safe treatment for pediatric patients with PWS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29885812</pmid><doi>10.1016/j.pdpdt.2018.06.006</doi><tpages>4</tpages></addata></record> |
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| ispartof | Photodiagnosis and photodynamic therapy, 2018-09, Vol.23, p.102-105 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Child Child, Preschool Chinese pediatric patients Female Hematoporphyrin monomethyl ether Hematoporphyrins - administration & dosage Humans Infant Male Photochemotherapy - adverse effects Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Port-wine stain Port-Wine Stain - drug therapy |
| title | A clinical study of HMME-PDT therapy in Chinese pediatric patients with port-wine stain |
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