Targeting tryptophan availability to tumors: the answer to immune escape?

Tumoral immune escape is an obstacle to successful cancer therapy. Tryptophan (Trp) metabolites along the kynurenine pathway induce immunosuppression involving apoptosis of effector immune cells, which tumors use to escape an immune response. Production of these metabolites is initiated by indoleami...

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Veröffentlicht in:	Immunology and cell biology 2018-11, Vol.96 (10), p.1026-1034
1. Verfasser:	Badawy, Abdulla A‐B
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Albumins - metabolism Amino acids Animals Apoptosis Biomarkers Cancer Cancer immunotherapy Cancer therapies Cytokines Effector cells Fatty Acids - metabolism Glucocorticoids Humans Immune evasion Immune response Immunology Immunosuppression Immunotherapy indoleamine 2,3‐dioxygenase Kynurenine - metabolism Metabolic Networks and Pathways - drug effects Metabolites Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - etiology Neoplasms - metabolism Nicotinamide non‐esterified fatty acids plasma free tryptophan Tryptophan Tryptophan - blood Tryptophan - metabolism Tryptophan 2,3-dioxygenase Tryptophan transporters Tumor Escape - drug effects Tumors α‐methyltryptophan
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