Effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction
To investigate the effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO) and to observe the effect of fluorofenidone on the expressions of collagen type I (Col I), collagen type III (Col III), α-smooth muscle actin (α-SMA), connective tissue growt...
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| Veröffentlicht in: | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2018-05, Vol.43 (5), p.511-519 |
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| container_title | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban |
| container_volume | 43 |
| creator | Tan, Wenqing Wang, Wei Zheng, Xuan Chen, Jiying Yuan, Xiangning Zhang, Fangfang Wang, Shuting Tao, Lijian |
| description | To investigate the effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO) and to observe the effect of fluorofenidone on the expressions of collagen type I (Col I), collagen type III (Col III), α-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), platelet derived growth factor (PDGF) in the renal tissues of UUO rats.
Methods: Male Sprague-Dawley (SD) rats were randomly divided into a sham-operated group, a UUO group, and a flurofenidone group (n=5). UUO model was induced by ligating the left ureter in rats. The rats were treated with 125 mg/(kg.d) fluorofenidone by gastric gavage in the fluorofenidone group at 24 h before the operation, and the rats were treated with the identical dose of 0.5% sodium carboxyl methyl cellulose (CMC-Na) in the other 2 groups. The rats were sacrificed at 14 days after UUO. Pathological changes of the renal tissue were observed by HE and Masson staining, the mRNA expressions of Col I, Col III, α-SMA, PDGF and |
| doi_str_mv | 10.11817/j.issn.1672-7347.2018.05.009 |
| format | Article |
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Methods: Male Sprague-Dawley (SD) rats were randomly divided into a sham-operated group, a UUO group, and a flurofenidone group (n=5). UUO model was induced by ligating the left ureter in rats. The rats were treated with 125 mg/(kg.d) fluorofenidone by gastric gavage in the fluorofenidone group at 24 h before the operation, and the rats were treated with the identical dose of 0.5% sodium carboxyl methyl cellulose (CMC-Na) in the other 2 groups. The rats were sacrificed at 14 days after UUO. Pathological changes of the renal tissue were observed by HE and Masson staining, the mRNA expressions of Col I, Col III, α-SMA, PDGF and</description><identifier>ISSN: 1672-7347</identifier><identifier>DOI: 10.11817/j.issn.1672-7347.2018.05.009</identifier><identifier>PMID: 29886467</identifier><language>chi</language><publisher>China</publisher><subject>Actins - metabolism ; Animals ; Collagen Type I - metabolism ; Collagen Type III - metabolism ; Connective Tissue Growth Factor - metabolism ; Fibrosis ; Gastric Lavage ; Kidney - drug effects ; Kidney - metabolism ; Kidney Diseases - complications ; Kidney Diseases - drug therapy ; Kidney Diseases - metabolism ; Kidney Diseases - pathology ; Ligation ; Male ; Platelet-Derived Growth Factor - metabolism ; Pyridones - pharmacology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Ureteral Obstruction - etiology</subject><ispartof>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2018-05, Vol.43 (5), p.511-519</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29886467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Wenqing</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Zheng, Xuan</creatorcontrib><creatorcontrib>Chen, Jiying</creatorcontrib><creatorcontrib>Yuan, Xiangning</creatorcontrib><creatorcontrib>Zhang, Fangfang</creatorcontrib><creatorcontrib>Wang, Shuting</creatorcontrib><creatorcontrib>Tao, Lijian</creatorcontrib><title>Effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction</title><title>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</title><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><description>To investigate the effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO) and to observe the effect of fluorofenidone on the expressions of collagen type I (Col I), collagen type III (Col III), α-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), platelet derived growth factor (PDGF) in the renal tissues of UUO rats.
Methods: Male Sprague-Dawley (SD) rats were randomly divided into a sham-operated group, a UUO group, and a flurofenidone group (n=5). UUO model was induced by ligating the left ureter in rats. The rats were treated with 125 mg/(kg.d) fluorofenidone by gastric gavage in the fluorofenidone group at 24 h before the operation, and the rats were treated with the identical dose of 0.5% sodium carboxyl methyl cellulose (CMC-Na) in the other 2 groups. The rats were sacrificed at 14 days after UUO. Pathological changes of the renal tissue were observed by HE and Masson staining, the mRNA expressions of Col I, Col III, α-SMA, PDGF and</description><subject>Actins - metabolism</subject><subject>Animals</subject><subject>Collagen Type I - metabolism</subject><subject>Collagen Type III - metabolism</subject><subject>Connective Tissue Growth Factor - metabolism</subject><subject>Fibrosis</subject><subject>Gastric Lavage</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - drug therapy</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - pathology</subject><subject>Ligation</subject><subject>Male</subject><subject>Platelet-Derived Growth Factor - metabolism</subject><subject>Pyridones - pharmacology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Ureteral Obstruction - etiology</subject><issn>1672-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhbNQbKn9C5KN4GbGPGaSyVJKfUDBTfdDkkkwMpPUPBD_vYFWV-eej4-7OADcY9RiPGD--Nm6lHyLGScNpx1vCcJDi_oWIXEF1v98BbYpOVWpEJQN_AasiBgG1jG-BtPeWqMzDBbauYQYrPFuCt7A4GE0Xs7Q-Wxiyi67WqxTMSSXKoVR5gS_Xf6AxbtZVqsKJZrzEVTKsejsgr8F11bOyWwvuQHH5_1x99oc3l_edk-H5tQz3uiOTdb0clAKa8MkkmLqe2KxnKS1BGuOEZUSY2Q7QrHWyjJleiFFVXRH6QY8nN-eYvgqJuVxcUmbeZbehJJGgnpKOBnqDBtwd1GLWsw0nqJbZPwZ_4ahv6inaxg</recordid><startdate>20180528</startdate><enddate>20180528</enddate><creator>Tan, Wenqing</creator><creator>Wang, Wei</creator><creator>Zheng, Xuan</creator><creator>Chen, Jiying</creator><creator>Yuan, Xiangning</creator><creator>Zhang, Fangfang</creator><creator>Wang, Shuting</creator><creator>Tao, Lijian</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20180528</creationdate><title>Effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction</title><author>Tan, Wenqing ; Wang, Wei ; Zheng, Xuan ; Chen, Jiying ; Yuan, Xiangning ; Zhang, Fangfang ; Wang, Shuting ; Tao, Lijian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p567-c46dfe5a8bb1ce6a0a9d552f1adaff21c7103aa110f4231ccbf6be59a9f1ac433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2018</creationdate><topic>Actins - metabolism</topic><topic>Animals</topic><topic>Collagen Type I - metabolism</topic><topic>Collagen Type III - metabolism</topic><topic>Connective Tissue Growth Factor - metabolism</topic><topic>Fibrosis</topic><topic>Gastric Lavage</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - drug therapy</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - pathology</topic><topic>Ligation</topic><topic>Male</topic><topic>Platelet-Derived Growth Factor - metabolism</topic><topic>Pyridones - pharmacology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Ureteral Obstruction - etiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Tan, Wenqing</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Zheng, Xuan</creatorcontrib><creatorcontrib>Chen, Jiying</creatorcontrib><creatorcontrib>Yuan, Xiangning</creatorcontrib><creatorcontrib>Zhang, Fangfang</creatorcontrib><creatorcontrib>Wang, Shuting</creatorcontrib><creatorcontrib>Tao, Lijian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Wenqing</au><au>Wang, Wei</au><au>Zheng, Xuan</au><au>Chen, Jiying</au><au>Yuan, Xiangning</au><au>Zhang, Fangfang</au><au>Wang, Shuting</au><au>Tao, Lijian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction</atitle><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><date>2018-05-28</date><risdate>2018</risdate><volume>43</volume><issue>5</issue><spage>511</spage><epage>519</epage><pages>511-519</pages><issn>1672-7347</issn><abstract>To investigate the effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO) and to observe the effect of fluorofenidone on the expressions of collagen type I (Col I), collagen type III (Col III), α-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), platelet derived growth factor (PDGF) in the renal tissues of UUO rats.
Methods: Male Sprague-Dawley (SD) rats were randomly divided into a sham-operated group, a UUO group, and a flurofenidone group (n=5). UUO model was induced by ligating the left ureter in rats. The rats were treated with 125 mg/(kg.d) fluorofenidone by gastric gavage in the fluorofenidone group at 24 h before the operation, and the rats were treated with the identical dose of 0.5% sodium carboxyl methyl cellulose (CMC-Na) in the other 2 groups. The rats were sacrificed at 14 days after UUO. Pathological changes of the renal tissue were observed by HE and Masson staining, the mRNA expressions of Col I, Col III, α-SMA, PDGF and</abstract><cop>China</cop><pmid>29886467</pmid><doi>10.11817/j.issn.1672-7347.2018.05.009</doi><tpages>9</tpages></addata></record> |
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| ispartof | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2018-05, Vol.43 (5), p.511-519 |
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| language | chi |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Actins - metabolism Animals Collagen Type I - metabolism Collagen Type III - metabolism Connective Tissue Growth Factor - metabolism Fibrosis Gastric Lavage Kidney - drug effects Kidney - metabolism Kidney Diseases - complications Kidney Diseases - drug therapy Kidney Diseases - metabolism Kidney Diseases - pathology Ligation Male Platelet-Derived Growth Factor - metabolism Pyridones - pharmacology Random Allocation Rats Rats, Sprague-Dawley Ureteral Obstruction - etiology |
| title | Effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction |
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