A survey of the effects of ramelteon on benzodiazepine-dependence: Comparison between a ramelteon add-on group and a continuous benzodiazepine administration group

•Ramelteon use for long-term insomnia treatment has not been sufficiently examined.•We propose gradual dose reduction of benzodiazepine sleeping agents by ramelteon addition.•Ramelteon-containing regimens improved patient symptoms and quality of life. In general, long-term benzodiazepine hypnotics a...

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