Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine

A series of new dithiocarbamates containing a 2(5H)-furanone-piperazine group was synthesized. These compounds show good in vitro cytoxic activity. Among them, compound 6c exhibits the best inhibitory activity against HeLa cell lines with an IC50 of 0.06 ± 0.01 μM for 72 h, and it has good inhibitor...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-07, Vol.155, p.165-170
Hauptverfasser:	Wei, Meng-Xue, Zhang, Jiao, Ma, Fu-Li, Li, Ming, Yu, Jia-Ying, Luo, Wei, Li, Xue-Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	2(5H)-Furanone Biological activities Dithiocarbamates SMMC-7721 cell lines Synthesis
Online-Zugang:	Volltext
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