Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide

Copper and zinc play important roles in Alzheimer disease pathology with recent reports describing potential therapeutics based on modulation of metal bioavailability. We examined the ability of a range of metal bis(thiosemicarbazonato) complexes (MII(btsc), where M = CuII or ZnII) to increase intra...

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Veröffentlicht in:	The Journal of biological chemistry 2008-02, Vol.283 (8), p.4568-4577
Hauptverfasser:	Donnelly, Paul S., Caragounis, Aphrodite, Du, Tai, Laughton, Katrina M., Volitakis, Irene, Cherny, Robert A., Sharples, Robyn A., Hill, Andrew F., Li, Qiao-Xin, Masters, Colin L., Barnham, Kevin J., White, Anthony R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Biological Availability CHO Cells Copper - pharmacokinetics Copper - pharmacology Copper - therapeutic use Cricetinae Cricetulus Dose-Response Relationship, Drug Drug Evaluation, Preclinical Gene Expression Humans Oxidation-Reduction - drug effects Thiosemicarbazones - pharmacokinetics Thiosemicarbazones - pharmacology Thiosemicarbazones - therapeutic use Zinc - chemistry Zinc - pharmacokinetics Zinc - pharmacology Zinc - therapeutic use
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