Human fetal testis Leydig cell disruption by exposure to the pesticide dieldrin at low concentrations

BACKGROUND Declining human reproductive health over the last 60 years has been proposed to be due to effects of environmental chemicals, especially endocrine disrupting compounds, on fetal development. We investigated whether a model pesticide, dieldrin, at concentrations within both maternal circul...

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Veröffentlicht in:	Human reproduction (Oxford) 2007-11, Vol.22 (11), p.2919-2927
Hauptverfasser:	Fowler, Paul A., Abramovich, David R., Haites, Neva E., Cash, Phillip, Groome, Nigel P., Al-Qahtani, Ahmed, Murray, Tessa J., Lea, Richard G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells, Cultured Dieldrin - toxicity endocrine disruption Female fetal Gonadotropins - metabolism Gynecology. Andrology. Obstetrics human Humans Immunohistochemistry - methods Leydig Cells - cytology Leydig Cells - drug effects Male Medical sciences pesticide Pesticides - toxicity Phosphoproteins - biosynthesis Pregnancy Pregnancy Trimester, Second Proteome testis Testis - drug effects Testis - embryology Testosterone - biosynthesis
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