Effects of fluoxetine exposure on serotonin-related activity in the sheepshead minnow ( Cyprinodon variegatus) using LC/MS/MS detection and quantitation

Fluoxetine (FLX) is a selective serotonin reuptake inhibitor and is among the top 100 drugs prescribed yearly in the United States and the United Kingdom. Tissue and water extraction methods were developed to detect and quantify FLX, norfluoxetine and the associated biological compounds serotonin (5...

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Veröffentlicht in:	Comparative biochemistry and physiology. Toxicology & pharmacology 2009-05, Vol.149 (4), p.559-565
Hauptverfasser:	Winder, V.L., Sapozhnikova, Y., Pennington, P.L., Wirth, E.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Liquid Cyprinodon variegatus Environmental Exposure Fluoxetine Fluoxetine - pharmacology Fluoxetine - toxicity Freshwater Hydroxyindoleacetic Acid - metabolism Inhibitory Concentration 50 Killifishes - metabolism LC/MS/MS Melatonin - metabolism minnow Pharmaceuticals Serotonin Serotonin - physiology Serotonin Uptake Inhibitors - pharmacology Tandem Mass Spectrometry Tryptophan Tryptophan - metabolism
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