Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARγ signaling

Polychlorinated biphenyls (PCBs) exposure is closely associated with obesity and diabetes. However, the mechanism of PCBs-induced adiposity and insulin resistance is not clear and the intervention is limited. We have found that oleanolic acid (OA) is a natural triterpenoid, possessing antioxidant an...

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Veröffentlicht in:	Free radical biology & medicine 2018-08, Vol.124, p.122-134
Hauptverfasser:	Su, Shuhao, Wu, Guangyuan, Cheng, Xiaodong, Fan, Junshu, Peng, Jie, Su, Hongfei, Xu, Zhongrui, Cao, Meng, Long, Zi, Hao, Yiming, Li, Ge, Li, Shuang, Hai, Chunxu, Wang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Hepatocyte nuclear factor 1b Metabolic dysfunction Oleanolic acid Oxidative stress Polychlorinated biphenyls Vitamin C
Online-Zugang:	Volltext
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