Direct Genetic and Enzymatic Evidence for Oxidative Cyclization in Hygromycin B Biosynthesis

Hygromycin B is an aminoglycoside antibiotic with a structurally distinctive orthoester linkage. Despite its long history of use in industry and in the laboratory, its biosynthesis remains poorly understood. We show here, by in-frame gene deletion in vivo and detailed enzyme characterization in vitr...

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Veröffentlicht in:	ACS chemical biology 2018-08, Vol.13 (8), p.2203-2210
Hauptverfasser:	Li, Sicong, Zhang, Jun, Liu, Yuanzhen, Sun, Guo, Deng, Zixin, Sun, Yuhui
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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