Association of circulating proinflammatory marker, leucine‐rich‐α2‐glycoprotein (LRG1), following metabolic/bariatric surgery
Background Obesity confers substantial excess risk for morbidity and mortality, especially for type 2 diabetes (T2D). Leucine‐rich‐α2‐glycoprotein 1 (LRG1), a novel proinflammatory factor, was recently reported to be higher in patients with T2D with complications of peripheral arterial disease. Asso...
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| creator | Pek, Sharon Li Ting Cheng, Anton Kui Sing Lin, Michelle Xueqin Wong, Moh Sim Chan, Eric Zit Liang Moh, Angela Mei Chung Sum, Chee Fang Lim, Su Chi Tavintharan, Subramaniam |
| description | Background
Obesity confers substantial excess risk for morbidity and mortality, especially for type 2 diabetes (T2D). Leucine‐rich‐α2‐glycoprotein 1 (LRG1), a novel proinflammatory factor, was recently reported to be higher in patients with T2D with complications of peripheral arterial disease. Association of LRG1, obesity, and weight loss is unknown. We examined whether plasma LRG1 is associated with obesity in health screening participants and if it predicts future weight loss in morbidly obese patients after metabolic/bariatric surgery.
Methods
Cohort 1 was a cross‐sectional study from a Health Screening program (n = 616) in a tertiary hospital. Cohort 2 was a prospective study of morbidly obese patients (n = 231) who underwent metabolic/bariatric surgery with follow‐up weight measurements. Anthropometric data, baseline fasting glucose, plasma adiponectin, high sensitivity C‐reactive protein (HsCRP), and LRG1 were measured. Postsurgery blood, after metabolic/bariatric surgery, were available for LRG1and HsCRP measurements in 57 patients.
Results
In the group with highest tertile of LRG1, body mass index (BMI), waist circumference, and HsCRP were significantly higher, while total cholesterol, high‐density lipoprotein, low‐density lipoprotein, and adiponectin were lower than tertiles 1 and 2. Generalized linear model analysis showed that female gender (P |
| doi_str_mv | 10.1002/dmrr.3029 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2052808833</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2052808833</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3349-9e03007a744f716d306e21e4565b17f5cafbb6b499dc4124f18dd5a946f78b4e3</originalsourceid><addsrcrecordid>eNp1kU9O3DAUhy1UBJR20QugSN2AxDD-m8RLBC1FGlRp1K4tx3meGpwY7EQoOxYcoFfpRXqInqSeDrBA6sbPlr73-en9EPpA8AnBmM7bLsYThqncQntEUDyrRInfvNwF3UVvU7rGGDNe8h20S2VdMyzEHno8TSkYpwcX-iLYwrhoRp-f_aq4jcH11uuu00OIU9HpeAPxuPAwGtfDn4ef0Zkfufz-RfO58pMJuWcA1xeHi-UFOToubPA-3K9tHQy6Cd6ZeaNj_jD3FmmMK4jTO7RttU_w_qnuo--fP307-zJbfL24PDtdzAxjXM4kYIZxpSvObUXKluESKAEuStGQygqjbdOUDZeyNZxQbkndtkJLXtqqbjiwfXS48eYp70ZIg-pcMuC97iGMSVEsaI3zalhGP75Cr8MY-zydooQIWUlCqkwdbSgTQ0oRrLqNLq9pUgSrdTRqHY1aR5PZgyfj2HTQvpDPWWRgvgHunYfp_yZ1frVc_lP-BVnendI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2115979117</pqid></control><display><type>article</type><title>Association of circulating proinflammatory marker, leucine‐rich‐α2‐glycoprotein (LRG1), following metabolic/bariatric surgery</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Pek, Sharon Li Ting ; Cheng, Anton Kui Sing ; Lin, Michelle Xueqin ; Wong, Moh Sim ; Chan, Eric Zit Liang ; Moh, Angela Mei Chung ; Sum, Chee Fang ; Lim, Su Chi ; Tavintharan, Subramaniam</creator><creatorcontrib>Pek, Sharon Li Ting ; Cheng, Anton Kui Sing ; Lin, Michelle Xueqin ; Wong, Moh Sim ; Chan, Eric Zit Liang ; Moh, Angela Mei Chung ; Sum, Chee Fang ; Lim, Su Chi ; Tavintharan, Subramaniam</creatorcontrib><description>Background
Obesity confers substantial excess risk for morbidity and mortality, especially for type 2 diabetes (T2D). Leucine‐rich‐α2‐glycoprotein 1 (LRG1), a novel proinflammatory factor, was recently reported to be higher in patients with T2D with complications of peripheral arterial disease. Association of LRG1, obesity, and weight loss is unknown. We examined whether plasma LRG1 is associated with obesity in health screening participants and if it predicts future weight loss in morbidly obese patients after metabolic/bariatric surgery.
Methods
Cohort 1 was a cross‐sectional study from a Health Screening program (n = 616) in a tertiary hospital. Cohort 2 was a prospective study of morbidly obese patients (n = 231) who underwent metabolic/bariatric surgery with follow‐up weight measurements. Anthropometric data, baseline fasting glucose, plasma adiponectin, high sensitivity C‐reactive protein (HsCRP), and LRG1 were measured. Postsurgery blood, after metabolic/bariatric surgery, were available for LRG1and HsCRP measurements in 57 patients.
Results
In the group with highest tertile of LRG1, body mass index (BMI), waist circumference, and HsCRP were significantly higher, while total cholesterol, high‐density lipoprotein, low‐density lipoprotein, and adiponectin were lower than tertiles 1 and 2. Generalized linear model analysis showed that female gender (P < .0001), non‐Chinese ethnicity (P < .019), and higher HsCRP (P < .0001) levels were independent and significant determinants of higher plasma LRG1 levels. After adjustment for age, gender, ethnicity, and baseline BMI, female gender (P = .020), higher presurgery BMI (P = .001), and lower presurgery LRG1 (P = .002) remained statistically significant predictors for greater weight loss. Plasma LRG1 increased significantly [from 28.2 (21.9‐36.8) to 34.9 (22.6‐49.5)] μg/mL (P = .003) within 1.5 months, after metabolic/bariatric surgery.
Conclusions
Our study demonstrates that LRG1 level is positively associated with obesity and a lower level of plasma LRG1 predicts weight loss in metabolic/bariatric surgery. Our novel findings suggest LRG1, itself or in combination with other known factors, is a potential biomarker of inflammation and obesity.</description><identifier>ISSN: 1520-7552</identifier><identifier>EISSN: 1520-7560</identifier><identifier>DOI: 10.1002/dmrr.3029</identifier><identifier>PMID: 29883055</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adiponectin ; Adolescent ; Adult ; Aged ; Bariatric Surgery ; Biomarkers - blood ; Body mass index ; Body weight loss ; Cholesterol ; Cohort Studies ; Cross-Sectional Studies ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Ethnicity ; Female ; Gastrointestinal surgery ; Gender ; Glycoproteins - blood ; Humans ; Inflammation ; Inflammation - blood ; Inflammation - complications ; Inflammation Mediators - blood ; Leucine ; Leucine‐rich‐α2‐glycoprotein ; LRG1 ; Male ; Medical screening ; metabolic/bariatric surgery ; Metabolism ; Middle Aged ; Minority & ethnic groups ; Morbidity ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - complications ; Obesity, Morbid - surgery ; Plasma ; Postoperative Period ; Statistical analysis ; Surgery ; Weight control ; Young Adult</subject><ispartof>Diabetes/metabolism research and reviews, 2018-10, Vol.34 (7), p.e3029-n/a</ispartof><rights>2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3349-9e03007a744f716d306e21e4565b17f5cafbb6b499dc4124f18dd5a946f78b4e3</citedby><cites>FETCH-LOGICAL-c3349-9e03007a744f716d306e21e4565b17f5cafbb6b499dc4124f18dd5a946f78b4e3</cites><orcidid>0000-0001-7047-1420</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdmrr.3029$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdmrr.3029$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29883055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pek, Sharon Li Ting</creatorcontrib><creatorcontrib>Cheng, Anton Kui Sing</creatorcontrib><creatorcontrib>Lin, Michelle Xueqin</creatorcontrib><creatorcontrib>Wong, Moh Sim</creatorcontrib><creatorcontrib>Chan, Eric Zit Liang</creatorcontrib><creatorcontrib>Moh, Angela Mei Chung</creatorcontrib><creatorcontrib>Sum, Chee Fang</creatorcontrib><creatorcontrib>Lim, Su Chi</creatorcontrib><creatorcontrib>Tavintharan, Subramaniam</creatorcontrib><title>Association of circulating proinflammatory marker, leucine‐rich‐α2‐glycoprotein (LRG1), following metabolic/bariatric surgery</title><title>Diabetes/metabolism research and reviews</title><addtitle>Diabetes Metab Res Rev</addtitle><description>Background
Obesity confers substantial excess risk for morbidity and mortality, especially for type 2 diabetes (T2D). Leucine‐rich‐α2‐glycoprotein 1 (LRG1), a novel proinflammatory factor, was recently reported to be higher in patients with T2D with complications of peripheral arterial disease. Association of LRG1, obesity, and weight loss is unknown. We examined whether plasma LRG1 is associated with obesity in health screening participants and if it predicts future weight loss in morbidly obese patients after metabolic/bariatric surgery.
Methods
Cohort 1 was a cross‐sectional study from a Health Screening program (n = 616) in a tertiary hospital. Cohort 2 was a prospective study of morbidly obese patients (n = 231) who underwent metabolic/bariatric surgery with follow‐up weight measurements. Anthropometric data, baseline fasting glucose, plasma adiponectin, high sensitivity C‐reactive protein (HsCRP), and LRG1 were measured. Postsurgery blood, after metabolic/bariatric surgery, were available for LRG1and HsCRP measurements in 57 patients.
Results
In the group with highest tertile of LRG1, body mass index (BMI), waist circumference, and HsCRP were significantly higher, while total cholesterol, high‐density lipoprotein, low‐density lipoprotein, and adiponectin were lower than tertiles 1 and 2. Generalized linear model analysis showed that female gender (P < .0001), non‐Chinese ethnicity (P < .019), and higher HsCRP (P < .0001) levels were independent and significant determinants of higher plasma LRG1 levels. After adjustment for age, gender, ethnicity, and baseline BMI, female gender (P = .020), higher presurgery BMI (P = .001), and lower presurgery LRG1 (P = .002) remained statistically significant predictors for greater weight loss. Plasma LRG1 increased significantly [from 28.2 (21.9‐36.8) to 34.9 (22.6‐49.5)] μg/mL (P = .003) within 1.5 months, after metabolic/bariatric surgery.
Conclusions
Our study demonstrates that LRG1 level is positively associated with obesity and a lower level of plasma LRG1 predicts weight loss in metabolic/bariatric surgery. Our novel findings suggest LRG1, itself or in combination with other known factors, is a potential biomarker of inflammation and obesity.</description><subject>Adiponectin</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Bariatric Surgery</subject><subject>Biomarkers - blood</subject><subject>Body mass index</subject><subject>Body weight loss</subject><subject>Cholesterol</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Gender</subject><subject>Glycoproteins - blood</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - complications</subject><subject>Inflammation Mediators - blood</subject><subject>Leucine</subject><subject>Leucine‐rich‐α2‐glycoprotein</subject><subject>LRG1</subject><subject>Male</subject><subject>Medical screening</subject><subject>metabolic/bariatric surgery</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Morbidity</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - complications</subject><subject>Obesity, Morbid - surgery</subject><subject>Plasma</subject><subject>Postoperative Period</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Weight control</subject><subject>Young Adult</subject><issn>1520-7552</issn><issn>1520-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9O3DAUhy1UBJR20QugSN2AxDD-m8RLBC1FGlRp1K4tx3meGpwY7EQoOxYcoFfpRXqInqSeDrBA6sbPlr73-en9EPpA8AnBmM7bLsYThqncQntEUDyrRInfvNwF3UVvU7rGGDNe8h20S2VdMyzEHno8TSkYpwcX-iLYwrhoRp-f_aq4jcH11uuu00OIU9HpeAPxuPAwGtfDn4ef0Zkfufz-RfO58pMJuWcA1xeHi-UFOToubPA-3K9tHQy6Cd6ZeaNj_jD3FmmMK4jTO7RttU_w_qnuo--fP307-zJbfL24PDtdzAxjXM4kYIZxpSvObUXKluESKAEuStGQygqjbdOUDZeyNZxQbkndtkJLXtqqbjiwfXS48eYp70ZIg-pcMuC97iGMSVEsaI3zalhGP75Cr8MY-zydooQIWUlCqkwdbSgTQ0oRrLqNLq9pUgSrdTRqHY1aR5PZgyfj2HTQvpDPWWRgvgHunYfp_yZ1frVc_lP-BVnendI</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Pek, Sharon Li Ting</creator><creator>Cheng, Anton Kui Sing</creator><creator>Lin, Michelle Xueqin</creator><creator>Wong, Moh Sim</creator><creator>Chan, Eric Zit Liang</creator><creator>Moh, Angela Mei Chung</creator><creator>Sum, Chee Fang</creator><creator>Lim, Su Chi</creator><creator>Tavintharan, Subramaniam</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7047-1420</orcidid></search><sort><creationdate>201810</creationdate><title>Association of circulating proinflammatory marker, leucine‐rich‐α2‐glycoprotein (LRG1), following metabolic/bariatric surgery</title><author>Pek, Sharon Li Ting ; Cheng, Anton Kui Sing ; Lin, Michelle Xueqin ; Wong, Moh Sim ; Chan, Eric Zit Liang ; Moh, Angela Mei Chung ; Sum, Chee Fang ; Lim, Su Chi ; Tavintharan, Subramaniam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3349-9e03007a744f716d306e21e4565b17f5cafbb6b499dc4124f18dd5a946f78b4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adiponectin</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Bariatric Surgery</topic><topic>Biomarkers - blood</topic><topic>Body mass index</topic><topic>Body weight loss</topic><topic>Cholesterol</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Gender</topic><topic>Glycoproteins - blood</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - complications</topic><topic>Inflammation Mediators - blood</topic><topic>Leucine</topic><topic>Leucine‐rich‐α2‐glycoprotein</topic><topic>LRG1</topic><topic>Male</topic><topic>Medical screening</topic><topic>metabolic/bariatric surgery</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Morbidity</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - complications</topic><topic>Obesity, Morbid - surgery</topic><topic>Plasma</topic><topic>Postoperative Period</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Weight control</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pek, Sharon Li Ting</creatorcontrib><creatorcontrib>Cheng, Anton Kui Sing</creatorcontrib><creatorcontrib>Lin, Michelle Xueqin</creatorcontrib><creatorcontrib>Wong, Moh Sim</creatorcontrib><creatorcontrib>Chan, Eric Zit Liang</creatorcontrib><creatorcontrib>Moh, Angela Mei Chung</creatorcontrib><creatorcontrib>Sum, Chee Fang</creatorcontrib><creatorcontrib>Lim, Su Chi</creatorcontrib><creatorcontrib>Tavintharan, Subramaniam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes/metabolism research and reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pek, Sharon Li Ting</au><au>Cheng, Anton Kui Sing</au><au>Lin, Michelle Xueqin</au><au>Wong, Moh Sim</au><au>Chan, Eric Zit Liang</au><au>Moh, Angela Mei Chung</au><au>Sum, Chee Fang</au><au>Lim, Su Chi</au><au>Tavintharan, Subramaniam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of circulating proinflammatory marker, leucine‐rich‐α2‐glycoprotein (LRG1), following metabolic/bariatric surgery</atitle><jtitle>Diabetes/metabolism research and reviews</jtitle><addtitle>Diabetes Metab Res Rev</addtitle><date>2018-10</date><risdate>2018</risdate><volume>34</volume><issue>7</issue><spage>e3029</spage><epage>n/a</epage><pages>e3029-n/a</pages><issn>1520-7552</issn><eissn>1520-7560</eissn><abstract>Background
Obesity confers substantial excess risk for morbidity and mortality, especially for type 2 diabetes (T2D). Leucine‐rich‐α2‐glycoprotein 1 (LRG1), a novel proinflammatory factor, was recently reported to be higher in patients with T2D with complications of peripheral arterial disease. Association of LRG1, obesity, and weight loss is unknown. We examined whether plasma LRG1 is associated with obesity in health screening participants and if it predicts future weight loss in morbidly obese patients after metabolic/bariatric surgery.
Methods
Cohort 1 was a cross‐sectional study from a Health Screening program (n = 616) in a tertiary hospital. Cohort 2 was a prospective study of morbidly obese patients (n = 231) who underwent metabolic/bariatric surgery with follow‐up weight measurements. Anthropometric data, baseline fasting glucose, plasma adiponectin, high sensitivity C‐reactive protein (HsCRP), and LRG1 were measured. Postsurgery blood, after metabolic/bariatric surgery, were available for LRG1and HsCRP measurements in 57 patients.
Results
In the group with highest tertile of LRG1, body mass index (BMI), waist circumference, and HsCRP were significantly higher, while total cholesterol, high‐density lipoprotein, low‐density lipoprotein, and adiponectin were lower than tertiles 1 and 2. Generalized linear model analysis showed that female gender (P < .0001), non‐Chinese ethnicity (P < .019), and higher HsCRP (P < .0001) levels were independent and significant determinants of higher plasma LRG1 levels. After adjustment for age, gender, ethnicity, and baseline BMI, female gender (P = .020), higher presurgery BMI (P = .001), and lower presurgery LRG1 (P = .002) remained statistically significant predictors for greater weight loss. Plasma LRG1 increased significantly [from 28.2 (21.9‐36.8) to 34.9 (22.6‐49.5)] μg/mL (P = .003) within 1.5 months, after metabolic/bariatric surgery.
Conclusions
Our study demonstrates that LRG1 level is positively associated with obesity and a lower level of plasma LRG1 predicts weight loss in metabolic/bariatric surgery. Our novel findings suggest LRG1, itself or in combination with other known factors, is a potential biomarker of inflammation and obesity.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29883055</pmid><doi>10.1002/dmrr.3029</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7047-1420</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1520-7552 |
| ispartof | Diabetes/metabolism research and reviews, 2018-10, Vol.34 (7), p.e3029-n/a |
| issn | 1520-7552 1520-7560 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adiponectin Adolescent Adult Aged Bariatric Surgery Biomarkers - blood Body mass index Body weight loss Cholesterol Cohort Studies Cross-Sectional Studies Diabetes mellitus Diabetes mellitus (non-insulin dependent) Ethnicity Female Gastrointestinal surgery Gender Glycoproteins - blood Humans Inflammation Inflammation - blood Inflammation - complications Inflammation Mediators - blood Leucine Leucine‐rich‐α2‐glycoprotein LRG1 Male Medical screening metabolic/bariatric surgery Metabolism Middle Aged Minority & ethnic groups Morbidity Obesity Obesity, Morbid - blood Obesity, Morbid - complications Obesity, Morbid - surgery Plasma Postoperative Period Statistical analysis Surgery Weight control Young Adult |
| title | Association of circulating proinflammatory marker, leucine‐rich‐α2‐glycoprotein (LRG1), following metabolic/bariatric surgery |
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