Inflammation-induced mTORC2-Akt-mTORC1 signaling promotes macrophage foam cell formation

The transformation of macrophages into lipid-loaded foam cells is a critical and early event in the pathogenesis of atherosclerosis. Several recent reports highlighted that induction of TLR4 signaling promotes macrophage foam cell formation; however, the underlying molecular mechanisms have not been...

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Veröffentlicht in:	Biochimie 2018-08, Vol.151, p.139-149
Hauptverfasser:	Banerjee, Dipanjan, Sinha, Archana, Saikia, Sudeshna, Gogoi, Bhaskarjyoti, Rathore, Arvind K., Das, Anindhya Sundar, Pal, Durba, Buragohain, Alak K., Dasgupta, Suman
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt phosphorylation Foam Cells - metabolism Humans Inflammation Inflammation - metabolism Macrophage foam cell Mechanistic Target of Rapamycin Complex 1 - metabolism Mechanistic Target of Rapamycin Complex 2 - chemistry Mechanistic Target of Rapamycin Complex 2 - metabolism mTORC2 Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Signal Transduction THP-1 Cells TLR4 signaling Toll-Like Receptor 4 - metabolism
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