S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

We had recently demonstrated that the racemic mixture of 19-hydroxyeicosatetraenoic acid (19-HETE) protects against angiotensin II (Ang II)-induced cardiac hypertrophy. Therefore, the purpose of this study was to investigate whether the R- or S-enantiomer of 19-HETE confers cardioprotection against...

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Veröffentlicht in:	Drug metabolism and disposition 2018-08, Vol.46 (8), p.1157-1168
Hauptverfasser:	Shoieb, Sherif M., El-Kadi, Ayman O.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Angiotensin Angiotensin II Arachidonate 12-lipoxygenase Atrial natriuretic peptide Catalysis Catalytic activity Cell lines Cyclooxygenase-2 Enantiomers Gene expression Heart Hypertrophy Interleukin 6 Interleukin 8 Lipoxygenase Liquid chromatography Liquid oxygen Mass spectrometry Mass spectroscopy Myosin Oxygenase Polymerase chain reaction Prostaglandin endoperoxide synthase Protein expression Proteins
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