Diesel exhaust particle promotes tumor lung metastasis via the induction of BLT1-mediated neutrophilic lung inflammation

•DEP exposure induced LTB4 production and neutrophils infiltration and promoted lung metastasis of 3LL or 4T1 tumor cells.•BLT1 blockade attenuated DEP-induced neutrophilic lung inflammation.•BLT1 blockade before inflammation onset, but not after tumor cell seeding inhibited DEP-enhanced lung metast...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2018-11, Vol.111, p.530-540
Hauptverfasser:	Li, Wenjing, Liu, Ting, Xiong, Yingluo, Lv, Jiaoyan, Cui, Xinyi, He, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Diesel exhaust particle Leukotriene B4-BLT1 axis Lung inflammation Metastasis Neutrophil
Online-Zugang:	Volltext
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