Impact of blinking on ocular surface and tear film parameters
To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology. A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 7...
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| Veröffentlicht in: | The ocular surface 2018-10, Vol.16 (4), p.424-429 |
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| creator | Wang, Michael T.M. Tien, Leslie Han, Alicia Lee, Jung Min Kim, Dabin Markoulli, Maria Craig, Jennifer P. |
| description | To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology.
A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session.
Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0.02), with an odds ratio (95% CI) of 2.2 (1.2–4.2) times. Participants exhibiting incomplete blinking had higher Ocular Surface Disease Index scores (18 ± 13 versus 12 ± 9, p = 0.01), and greater levels of meibomian gland dropout (41.3 ± 15.7% versus 27.5 ± 14.1%, p |
| doi_str_mv | 10.1016/j.jtos.2018.06.001 |
| format | Article |
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A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session.
Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0.02), with an odds ratio (95% CI) of 2.2 (1.2–4.2) times. Participants exhibiting incomplete blinking had higher Ocular Surface Disease Index scores (18 ± 13 versus 12 ± 9, p = 0.01), and greater levels of meibomian gland dropout (41.3 ± 15.7% versus 27.5 ± 14.1%, p < 0.001). Furthermore, poorer tear film lipid layer thickness, non-invasive tear film stability, expressed meibum quality, eyelid notching, and anterior blepharitis grades were also observed in those exhibiting incomplete blinking (all p < 0.05). Blink frequency did not correlate significantly with any ocular surface parameters (all p > 0.05).
Incomplete blinking was associated with a two-fold increased risk of dry eye disease. The greater levels of meibomian gland dropout, as well as poorer expressed meibum quality and tear film lipid layer thickness, observed would suggest that incomplete blinking may predispose towards the development of evaporative dry eye.</description><identifier>ISSN: 1542-0124</identifier><identifier>EISSN: 1937-5913</identifier><identifier>DOI: 10.1016/j.jtos.2018.06.001</identifier><identifier>PMID: 29883739</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blinking ; Dry eye ; Eyelid ; Meibomian gland ; Ocular surface ; Tear film</subject><ispartof>The ocular surface, 2018-10, Vol.16 (4), p.424-429</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-bcd438e4428c9b65fefa194f3fa9fa5a2a88c99e6d04c7e56c1c3580ed6836393</citedby><cites>FETCH-LOGICAL-c422t-bcd438e4428c9b65fefa194f3fa9fa5a2a88c99e6d04c7e56c1c3580ed6836393</cites><orcidid>0000-0001-8297-5319 ; 0000-0002-9227-5866</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29883739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Michael T.M.</creatorcontrib><creatorcontrib>Tien, Leslie</creatorcontrib><creatorcontrib>Han, Alicia</creatorcontrib><creatorcontrib>Lee, Jung Min</creatorcontrib><creatorcontrib>Kim, Dabin</creatorcontrib><creatorcontrib>Markoulli, Maria</creatorcontrib><creatorcontrib>Craig, Jennifer P.</creatorcontrib><title>Impact of blinking on ocular surface and tear film parameters</title><title>The ocular surface</title><addtitle>Ocul Surf</addtitle><description>To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology.
A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session.
Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0.02), with an odds ratio (95% CI) of 2.2 (1.2–4.2) times. Participants exhibiting incomplete blinking had higher Ocular Surface Disease Index scores (18 ± 13 versus 12 ± 9, p = 0.01), and greater levels of meibomian gland dropout (41.3 ± 15.7% versus 27.5 ± 14.1%, p < 0.001). Furthermore, poorer tear film lipid layer thickness, non-invasive tear film stability, expressed meibum quality, eyelid notching, and anterior blepharitis grades were also observed in those exhibiting incomplete blinking (all p < 0.05). Blink frequency did not correlate significantly with any ocular surface parameters (all p > 0.05).
Incomplete blinking was associated with a two-fold increased risk of dry eye disease. The greater levels of meibomian gland dropout, as well as poorer expressed meibum quality and tear film lipid layer thickness, observed would suggest that incomplete blinking may predispose towards the development of evaporative dry eye.</description><subject>Blinking</subject><subject>Dry eye</subject><subject>Eyelid</subject><subject>Meibomian gland</subject><subject>Ocular surface</subject><subject>Tear film</subject><issn>1542-0124</issn><issn>1937-5913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EoqXwBzigHLkk-JG4tgQHVPGoVIkLnC3HWSOHJC52gsS_x1ULR0672p0ZaT6ELgkuCCb8pi3a0ceCYiIKzAuMyRGaE8mWeSUJO057VdIcE1rO0FmMLcaMc0xP0YxKIdiSyTm6W_dbbcbM26zu3PDhhvfMD5k3U6dDFqdgtYFMD002QjpY1_XZVgfdwwghnqMTq7sIF4e5QG-PD6-r53zz8rRe3W9yU1I65rVpSiagLKkwsuaVBauJLC2zWlpdaapFekjgDS7NEipuiGGVwNBwwTiTbIGu97nb4D8niKPqXTTQdXoAP0VFcUUFZqlqktK91AQfYwCrtsH1OnwrgtUOm2rVDpvaYVOYq4Qtma4O-VPdQ_Nn-eWUBLd7AaSWXw6CisbBYKBxAcyoGu_-y_8BhNt-Bg</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Wang, Michael T.M.</creator><creator>Tien, Leslie</creator><creator>Han, Alicia</creator><creator>Lee, Jung Min</creator><creator>Kim, Dabin</creator><creator>Markoulli, Maria</creator><creator>Craig, Jennifer P.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8297-5319</orcidid><orcidid>https://orcid.org/0000-0002-9227-5866</orcidid></search><sort><creationdate>201810</creationdate><title>Impact of blinking on ocular surface and tear film parameters</title><author>Wang, Michael T.M. ; Tien, Leslie ; Han, Alicia ; Lee, Jung Min ; Kim, Dabin ; Markoulli, Maria ; Craig, Jennifer P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-bcd438e4428c9b65fefa194f3fa9fa5a2a88c99e6d04c7e56c1c3580ed6836393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Blinking</topic><topic>Dry eye</topic><topic>Eyelid</topic><topic>Meibomian gland</topic><topic>Ocular surface</topic><topic>Tear film</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Michael T.M.</creatorcontrib><creatorcontrib>Tien, Leslie</creatorcontrib><creatorcontrib>Han, Alicia</creatorcontrib><creatorcontrib>Lee, Jung Min</creatorcontrib><creatorcontrib>Kim, Dabin</creatorcontrib><creatorcontrib>Markoulli, Maria</creatorcontrib><creatorcontrib>Craig, Jennifer P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The ocular surface</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Michael T.M.</au><au>Tien, Leslie</au><au>Han, Alicia</au><au>Lee, Jung Min</au><au>Kim, Dabin</au><au>Markoulli, Maria</au><au>Craig, Jennifer P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of blinking on ocular surface and tear film parameters</atitle><jtitle>The ocular surface</jtitle><addtitle>Ocul Surf</addtitle><date>2018-10</date><risdate>2018</risdate><volume>16</volume><issue>4</issue><spage>424</spage><epage>429</epage><pages>424-429</pages><issn>1542-0124</issn><eissn>1937-5913</eissn><abstract>To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology.
A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session.
Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0.02), with an odds ratio (95% CI) of 2.2 (1.2–4.2) times. Participants exhibiting incomplete blinking had higher Ocular Surface Disease Index scores (18 ± 13 versus 12 ± 9, p = 0.01), and greater levels of meibomian gland dropout (41.3 ± 15.7% versus 27.5 ± 14.1%, p < 0.001). Furthermore, poorer tear film lipid layer thickness, non-invasive tear film stability, expressed meibum quality, eyelid notching, and anterior blepharitis grades were also observed in those exhibiting incomplete blinking (all p < 0.05). Blink frequency did not correlate significantly with any ocular surface parameters (all p > 0.05).
Incomplete blinking was associated with a two-fold increased risk of dry eye disease. The greater levels of meibomian gland dropout, as well as poorer expressed meibum quality and tear film lipid layer thickness, observed would suggest that incomplete blinking may predispose towards the development of evaporative dry eye.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29883739</pmid><doi>10.1016/j.jtos.2018.06.001</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8297-5319</orcidid><orcidid>https://orcid.org/0000-0002-9227-5866</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1542-0124 |
| ispartof | The ocular surface, 2018-10, Vol.16 (4), p.424-429 |
| issn | 1542-0124 1937-5913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2052803012 |
| source | Alma/SFX Local Collection |
| subjects | Blinking Dry eye Eyelid Meibomian gland Ocular surface Tear film |
| title | Impact of blinking on ocular surface and tear film parameters |
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