Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques

Purpose The ligand [ 11 C]PK11195 binds with high affinity and selectivity to peripheral benzodiazepine receptor, expressed in high amounts in macrophages. In humans, [ 11 C]PK11195 has been used successfully for the in vivo imaging of inflammatory processes of brain tissue. The purpose of this stud...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2009, Vol.36 (1), p.73-80
Hauptverfasser:	Laitinen, Iina, Marjamäki, Päivi, Någren, Kjell, Laine, V. Jukka O., Wilson, Ian, Leppänen, Pia, Ylä-Herttuala, Seppo, Roivainen, Anne, Knuuti, Juhani
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Aorta - pathology Atherosclerosis - metabolism Atherosclerosis - pathology Autoradiography Biomarkers - metabolism Carbon Radioisotopes - chemistry Cardiology Cardiovascular disease Feasibility Feasibility Studies Imaging Inflammation - metabolism Inflammation - pathology Isoquinolines - chemistry Isoquinolines - metabolism Isoquinolines - pharmacokinetics Male Medical imaging Medicine Medicine & Public Health Mice Nuclear Medicine Oncology Original Article Orthopedics Pharmaceuticals Radiology Rodents Tissue Distribution Veins & arteries
Online-Zugang:	Volltext
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