TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

TRF2 is a member of the telosome/shelterin complex, which helps maintain telomere integrity. Using an oriented peptide library based on a previously identified TRF2-interaction region to define a consensus sequence for binding, new proteins have been identified as TRF2 interactors and implicated in...

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Veröffentlicht in:	Nature structural & molecular biology 2009-04, Vol.16 (4), p.372-379
Hauptverfasser:	Lee, Ok-Hee, Safari, Amin, Qin, Jun, Chae, Heekyung Kate, Chen, Liuh-Yow, Kim, Hyeung, Songyang, Zhou, Liu, Dan, Lin, Shiaw-Yih, Xin, Huawei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Microscopy Biomedical and Life Sciences Cell Cycle Cell Line Cellular biology Cellular signal transduction Chromosome abnormalities Complications and side effects Deoxyribonucleic acid DNA DNA binding proteins DNA-Binding Proteins - metabolism Genetic aspects Humans Life Sciences Mammals Membrane Biology Molecular biology Mutagenesis, Site-Directed Nerve Tissue Proteins - metabolism Nuclear Proteins - metabolism Peptides Physiological aspects Protein Binding Protein Interaction Domains and Motifs Protein Interaction Mapping Protein Structure Proteins RNA-Binding Proteins - metabolism Signal transduction Telomere Telomeres Telomeric Repeat Binding Protein 2 - genetics Telomeric Repeat Binding Protein 2 - metabolism
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