Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats

Rationale Previous research indicates that progesterone (PROG) decreased cocaine-seeking behavior in female rats. This effect of PROG may be in part due to its metabolite allopregnanolone (ALLO), which has been shown to decrease the sensitizing effects of cocaine and reduce lethality associated with...

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Veröffentlicht in:	Psychopharmacologia 2009-03, Vol.203 (1), p.63-72
Hauptverfasser:	Anker, Justin J., Holtz, Nathan A., Zlebnik, Natalie, Carroll, Marilyn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors Addictive behaviors Animals Behavior, Addictive Behavior, Animal - drug effects Biological and medical sciences Biomedical and Life Sciences Biomedicine Central Nervous System Stimulants - administration & dosage Cocaine Cocaine - administration & dosage Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - psychology Conditioning, Operant - drug effects Drug addiction Effects Enzyme Inhibitors - pharmacology Extinction, Psychological Female Finasteride - pharmacology Hormones Infusions, Intravenous Injections, Subcutaneous Male Medical sciences Models, Animal Motivation Motor Activity - drug effects Neuropharmacology Neurosciences Original Investigation Pharmacology. Drug treatments Pharmacology/Toxicology Pregnanolone - administration & dosage Pregnanolone - metabolism Pregnanolone - pharmacology Progesterone - administration & dosage Progesterone - metabolism Progesterone - pharmacology Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Rodents Self Administration Sex Factors Time Factors
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