Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene
1,3-Butadiene and chloroprene are multisite carcinogens in B6C3F1 mice with the strongest tumor response being the induction of lung neoplasms in females. Incidence of brain tumors in mice exposed to 1,3-butadiene was equivocal. This article reviews the efforts of our laboratory and others to uncove...
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| Veröffentlicht in: | Chemico-biological interactions 2007-03, Vol.166 (1), p.112-120 |
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| container_title | Chemico-biological interactions |
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| creator | Ton, Thai-Vu Hong, Hue-Hua Devereux, Theodora R. Melnick, Ronald L. Sills, Robert C. Kim, Yongbaek |
| description | 1,3-Butadiene and chloroprene are multisite carcinogens in B6C3F1 mice with the strongest tumor response being the induction of lung neoplasms in females. Incidence of brain tumors in mice exposed to 1,3-butadiene was equivocal. This article reviews the efforts of our laboratory and others to uncover the mechanisms of butadiene and chloroprene induced lung and brain tumor responses in the B6C3F1 mouse. The formation of lung tumors by these chemicals involved mutations in the K-
ras cancer gene and loss of heterozygosity in the region of K-
ras on distal chromosome 6, while alterations in
p53 and
p16 were implicated in brain tumorigenesis. |
| doi_str_mv | 10.1016/j.cbi.2006.04.015 |
| format | Article |
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ras cancer gene and loss of heterozygosity in the region of K-
ras on distal chromosome 6, while alterations in
p53 and
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ras cancer gene and loss of heterozygosity in the region of K-
ras on distal chromosome 6, while alterations in
p53 and
p16 were implicated in brain tumorigenesis.</description><subject>1,3-Butadiene</subject><subject>Alleles</subject><subject>Animals</subject><subject>Brain</subject><subject>Brain Neoplasms - chemically induced</subject><subject>Brain Neoplasms - genetics</subject><subject>Butadienes - administration & dosage</subject><subject>Butadienes - toxicity</subject><subject>Carcinogenesis</subject><subject>Carcinogens - administration & dosage</subject><subject>Carcinogens - toxicity</subject><subject>Chloroprene</subject><subject>Chloroprene - administration & dosage</subject><subject>Chloroprene - toxicity</subject><subject>Chromosomes, Mammalian - drug effects</subject><subject>DNA Adducts - drug effects</subject><subject>DNA Adducts - metabolism</subject><subject>Female</subject><subject>Genes, Neoplasm - genetics</subject><subject>Genes, ras</subject><subject>Humans</subject><subject>Inhalation Exposure</subject><subject>K- ras</subject><subject>Loss of heterozygosity</subject><subject>Loss of Heterozygosity - drug effects</subject><subject>Lung</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Mice</subject><subject>Mutagenesis - drug effects</subject><subject>Mutation</subject><subject>p16</subject><subject>p53</subject><subject>Tumor</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uFDEQhC1ERJbAA3BBPnFiJv5Z27PiRFZJQIqUSzhbnnZP8GpmvNieCJ6Bl8bZXYlbTq1qfVVSdxHygbOWM64vdy30oRWM6ZatW8bVK7LinRGNMZ1-TVaMsU0jzMack7c576pkYs3ekHOuO80qsyJ_r5_cuLgS4kzjQB9xxhKAurFgOmwzDTMFNwOmJuHoCvoDddiPy_xI3expn1yVZZliynRIcaJXeitvOJ0CIMXf-5irr0TKP8umX4rzoWbQmCj8HGOK-1TlO3I2uDHj-9O8ID9urh-235q7-9vv2693DchOlEYA76UQUmi1HnoOUivgRm2kdMI5r7lWgzLKdALEoIQSvZFGSWfAewNCygvy6Zi7T_HXgrnYKWTAcXQzxiVbwRTfSK0ryI8gpJhzwsHuU5hc-mM5s88N2J2tDdjnBixb29pA9Xw8hS_9hP6_4_TyCnw5AlhPfAqYbIb6DEAfEkKxPoYX4v8BsPeWSQ</recordid><startdate>20070320</startdate><enddate>20070320</enddate><creator>Ton, Thai-Vu</creator><creator>Hong, Hue-Hua</creator><creator>Devereux, Theodora R.</creator><creator>Melnick, Ronald L.</creator><creator>Sills, Robert C.</creator><creator>Kim, Yongbaek</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20070320</creationdate><title>Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene</title><author>Ton, Thai-Vu ; 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Incidence of brain tumors in mice exposed to 1,3-butadiene was equivocal. This article reviews the efforts of our laboratory and others to uncover the mechanisms of butadiene and chloroprene induced lung and brain tumor responses in the B6C3F1 mouse. The formation of lung tumors by these chemicals involved mutations in the K-
ras cancer gene and loss of heterozygosity in the region of K-
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| subjects | 1,3-Butadiene Alleles Animals Brain Brain Neoplasms - chemically induced Brain Neoplasms - genetics Butadienes - administration & dosage Butadienes - toxicity Carcinogenesis Carcinogens - administration & dosage Carcinogens - toxicity Chloroprene Chloroprene - administration & dosage Chloroprene - toxicity Chromosomes, Mammalian - drug effects DNA Adducts - drug effects DNA Adducts - metabolism Female Genes, Neoplasm - genetics Genes, ras Humans Inhalation Exposure K- ras Loss of heterozygosity Loss of Heterozygosity - drug effects Lung Lung Neoplasms - chemically induced Lung Neoplasms - genetics Male Mice Mutagenesis - drug effects Mutation p16 p53 Tumor |
| title | Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene |
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