Preparation and Characterization of Doripenem-Loaded Microparticles for Pulmonary Delivery

Pneumonia is a bacterial lower respiratory tract infection that has a high morbidity rate. The gram-negative pathogen is a significant cause of nosocomial infections and ventilator-associated pneumonias and is mainly treated by carbapenems. Doripenem is a carbapenem drug, which has a broad-spectrum...

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Veröffentlicht in:	Journal of aerosol medicine 2018-12, Vol.31 (6), p.347-357
Hauptverfasser:	Yildiz-Peköz, Ayca, Akbal, Ozlem, Tekarslan, S Hande, Sagirli, A Olcay, Mulazimoglu, Lütfiye, Morina, Deniz, Cevher, Erdal
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerodynamic properties Aerodynamics Antibacterial activity Antibiotics Antimicrobial agents Binding sites Carbapenems Chitosan Cytotoxicity Drug delivery Drug dosages Drying Epithelial cells FDA approval Formulations Gelation Health technology assessment Infectious diseases Knowledge management Lactose Leucine Lungs Methods Microparticles Morbidity Nosocomial infection Nosocomial infections Pharmaceutical sciences Pharmacy Pneumonia Polyvinyl alcohol Production methods Ratios Respiratory tract Respiratory tract diseases Size distribution Solvents Studies Trehalose Urinary tract diseases Urinary tract infections Urogenital system Ventilators Zeta potential
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