Caveolin-1 regulates autophagy activity in thyroid follicular cells and is involved in Hashimoto’s thyroiditis disease

Hashimoto’s thyroiditis (HT) is considered a T helper-type 1 (Th1) cytokine-dominant autoimmune thyroid disease. Caveolin-1 (Cav-1), a part of the thyroxisome multiprotein complex, is localized at the apical pole of thyrocytes and is indispensable for synthesis of thyroid hormones and modulation of...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2018, Vol.65(9), pp.893-901
Hauptverfasser:	Lu, Qingyan, Luo, Xuan, Mao, Chaoming, Zheng, Tingting, Liu, Baocui, Dong, Xin, Zhou, Yuepeng, Xu, Chengcheng, Mou, Xiao, Wu, Fei, Bu, Ling, Yuan, Guoyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Autophagy - drug effects Autophagy - genetics Case-Control Studies Caveolin Caveolin 1 - genetics Caveolin 1 - physiology Caveolin-1 Cells, Cultured Cytokines Gene Knockdown Techniques Hashimoto Disease - genetics Hashimoto Disease - metabolism Hashimoto’s thyroiditis Humans IL-1β Interferon-gamma - pharmacology Interleukin-1beta - pharmacology Lymphocytes T mRNA Oxidative stress Phagocytosis Proteins Reactive oxygen species siRNA Th1 Cells - metabolism Th1 Cells - physiology Th1 cytokines Thyrocytes Thyroid diseases Thyroid Epithelial Cells - drug effects Thyroid Epithelial Cells - metabolism Thyroid Epithelial Cells - physiology Thyroid gland Thyroid hormones Thyroiditis γ-Interferon
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