Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey

We have studied the effects of stimulating the pedunculopontine nuclei through a fully implanted macroelectrode with a s.c. implantable pulse generator whose parameters can be programmed telemetrically, in a macaque before and after inducing Parkinsonian akinesia with MPTP. Our results show that in...

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Veröffentlicht in:	Neuroreport 2004-12, Vol.15 (17), p.2621-2624
Hauptverfasser:	Jenkinson, Ned, Nandi, Dipankar, Miall, R Chris, Stein, John F, Aziz, Tipu Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Deep Brain Stimulation Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Dose-Response Relationship, Radiation Functional Laterality - physiology Functional Laterality - radiation effects Macaca Macaca mulatta Male Medical sciences Movement - drug effects Movement - radiation effects Movement Disorders - etiology Movement Disorders - therapy Neurology Parkinsonian Disorders - complications Parkinsonian Disorders - therapy Pedunculopontine Tegmental Nucleus - radiation effects
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