NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis

Metastases, the spread of cancer cells to distant organs, cause the majority of cancer-related deaths. Few metastasis-specific driver mutations have been identified, suggesting aberrant gene regulation as a source of metastatic traits. However, how metastatic gene expression programs arise is poorly...

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Veröffentlicht in:	Cancer discovery 2018-07, Vol.8 (7), p.850-865
Hauptverfasser:	Rodrigues, Paulo, Patel, Saroor A, Harewood, Louise, Olan, Ioana, Vojtasova, Erika, Syafruddin, Saiful E, Zaini, M Nazhif, Richardson, Emma K, Burge, Johanna, Warren, Anne Y, Stewart, Grant D, Saeb-Parsy, Kourosh, Samarajiwa, Shamith A, Vanharanta, Sakari
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Cell Line, Tumor Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic Humans Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Lung Neoplasms - secondary Male Mice Mice, Inbred NOD Mice, SCID NF-kappa B - metabolism
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