Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance

The maintenance of genome stability is essential for an organism to avoid cell death and cancer. Based on screens for mutant sensitivity against DNA damaging agents a large number of DNA repair and DNA damage checkpoint genes have previously been identified in genetically amenable model organisms. T...

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Veröffentlicht in:	DNA repair 2009-05, Vol.8 (5), p.672-679
Hauptverfasser:	Deshpande, Gaurang P., Hayles, Jacqueline, Hoe, Kwang-Lae, Kim, Dong-Uk, Park, Han-Oh, Hartsuiker, Edgar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antineoplastic Agents, Alkylating - pharmacology Aprataxin Bacteriology Biological and medical sciences Cell cycle, cell proliferation Cell physiology CtIP DNA Damage - drug effects DNA damage checkpoint DNA Repair Fundamental and applied biological sciences. Psychology Gene Deletion Gene Library Genome, Fungal Genome-wide deletion library Genomic Instability Growth, nutrition, cell differenciation Humans Microbiology Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis. Repair Mutation - genetics Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Sequence Homology, Amino Acid Signal Transduction - drug effects
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