microRNA downregulation in plasmacytoid dendritic cells in interferon-positive systemic lupus erythematosus and antiphospholipid syndrome

Abstract Objective To investigate miRNA expression in relation to transcriptomic changes in plasmacytoid dendritic cells (pDCs) in SLE and APS. pDCs are major producers of IFNα in SLE and APS, and miRNAs are emerging as regulators of pDC activation. Methods miRNA and mRNA expression were measured by...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2018-09, Vol.57 (9), p.1669-1674
Hauptverfasser:	van den Hoogen, Lucas L, Rossato, Marzia, Lopes, Ana P, Pandit, Aridaman, Bekker, Cornelis P J, Fritsch-Stork, Ruth D E, van Roon, Joel A G, Radstake, Timothy R D J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiphospholipid syndrome Antiphospholipid Syndrome - genetics Antiphospholipid Syndrome - metabolism Apoptosis Autoimmune diseases Dendritic cells Dendritic Cells - metabolism Dendritic Cells - pathology Down-Regulation Female Gene expression Gene Expression Regulation Humans Interferon Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - metabolism Lupus Erythematosus, Systemic - pathology Male MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Molecular modelling RNA, Messenger - genetics Systemic lupus erythematosus TLR7 protein Toll-Like Receptor 7 - biosynthesis Toll-Like Receptor 7 - genetics Toll-like receptors α-Interferon
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